Malaysian Journal of Analytical Sciences Vol 26 No 1 (2022): 164 - 175

 

 

 

 

TEMPERATURE EFFECT ON THE ENCAPSULATION OF THE DRUG TETRACAINE HYDROCHLORIDE IN DIFFERENT CYCLODEXTRINS

 

(Kesan Suhu Terhadap Pengkapsulan Dadah Tetrakain Hidroklorida dalam Siklodekstrin yang Berbeza)

 

Houria Boudjoras, Teffaha Fergoug, Mansour Azayez*, Youcef Bouhadda, Noureddine Meddah-araibi, Cherifa Zelmat

 

Laboratory of Physical Chemistry of Macromolecular and Biological Interfaces,

Faculty of Exact Sciences,

University of Mustapha Stambouli, Mascara, Algeria

 

*Corresponding author:  m.azayez@univ-mascara.dz

 

 

Received: 25 September 2021; Accepted: 30 December 2021; Published: 25 February 2022

 

 

Abstract

The encapsulation of tetrakain hydrochloride (TC-HCl) in α-cyclodextrin (α-CD), β -cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HPβ-CD) has been studied by UV-Visible at different temsperatures. The appearance of isosbestic points as well as hyperchromic and bathochromic shifts on the different UV-Visible spectra confirm the complexes formation. From the complexation constants values the stability of the 1:1 type complexes is in the order of α-CD < HPβ-CD < β-CD and decreases with increasing temperature for each complex. All complexation processes are spontaneous, with a favorable enthalpic contribution and an unfavorable entropic term as deduced from Van't Hoff plot analysis. The negative values obtained for ∆Cp^o indicate that the apolar part of TC-HCl is encapsulated in the cavities of the CDs.

 

Keywords:  UV-Vis spectrophotometry, cyclodextrins, tetracaine drug, temperature effect, Van't Hoff analysis

 

Abstrak

Pengkapsulan tetrakain hidroklorida (TC, HCl) dalam α-siklodekstrin (α-CD), β-sikloododekstrin (β-CD) dan hidroksipropil-β-siklodekstrin (HPβ-CD) telah dikaji mengunakan spektrofotometri UV-cahaya nampak pada suhu yang berbeza. Kemunculan titik isosbestik serta pergeseran hipokromik dan bathokromik pada spektrum UV-cahaya nampak yang berbeza mengesahkan pembentukan kompleks. Daripada nilai pemalar kompleks, kestabilan kompleks jenis 1: 1 berada dalam urutan α-CD <HPβ-CD <β-CD dan menurun dengan kenaikan suhu bagi setiap kompleks. Semua proses pengkompleksan adalah spontan, dengan sumbangan entalpik yang menggalakkan dan istilah entropik yang tidak menguntungkan seperti hasil analisis plot Van't Hoff. Nilai negatif yang diperoleh untuk ∆Cp^o menunjukkan bahawa bahagian tidak berkutub TC-HCl dikemas dalam rongga CD.

 

Kata kunci:  spektrofotometri UV-cahaya nampak, siklodekstrin, dadah tetrakain, kesan suhu, analisis Van't Hoff

 

 

 

Graphical Abstract

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