Malaysian Journal of Analytical Sciences Vol 25 No 6 (2021): 998 - 1006

 

 

 

 

ANALYSIS OF SUGAR CONTENT IN SELECTED CHILDREN’S HEALTH SUPPLEMENTS IN MALAYSIA

 

(Analisa Kandungan Gula dalam Suplemen Kesihatan Kanak-Kanak Terpilih yang Biasa didapati di Malaysia)

 

Siok-Yee Chan1, Mazidatulakmam Miskam2, Shangeetha Ganesan2*

 

1School of Pharmaceutical Sciences

2School of Chemical Sciences

Universiti Sains Malaysia, 11800 USM, Penang, Malaysia

 

*Corresponding author:  shangeetha@usm.my

 

 

Received:  24 September 2021; Accepted: 7 November 2021; Published:  27 December 2021

 

 

Abstract

The aim of this study is to investigate the prevalence of the various types of sugars in over-the-counter children’s health supplements that are commonly available in Malaysia. In this study, a total of 13 children’s health supplement samples of four different brands (tablets, pastilles, gummies) of various flavors (orange, blackcurrant, strawberry, mixed berries, mango and peach) were sent to an independent laboratory and analyzed for the presence of fructose, glucose, galactose, sucrose, maltose, lactose and total sugar content. The sugar profiling was carried out using HPLC with refractive index (RI) detector. The results showed that all brands contain a considerable amount of sugar as compared to the label claimed active content. Although this is expected, as it is important for addition of sugars in supplements targeting children especially for ease of consumption. Peach flavored pastilles were found to contain the most amount of sucrose per piece followed by strawberry flavored gummies. Through this study we found that certain flavoring calls for more sugar content as compared to others. The findings further provide support for the need of more comprehensive sugar content and active ingredients labelling in health supplements.

 

Keywords:  health supplement, sugar, children, Malaysia, flavor

 

Abstrak

Tujuan kajian ini adalah untuk menyelidik kelaziman pelbagai jenis gula dalam suplemen kesihatan kanak-kanak yang biasanya terdapat di kaunter di Malaysia. Dalam kajian ini, sebanyak 13 sampel suplemen kesihatan kanak-kanak dari empat jenama yang berbeza (tablet, pastil, gummies) dengan pelbagai rasa (oren, anggur hitam, strawberi, campuran beri, mangga dan pic) telah dihantar ke makmal bebas dan dianalisis untuk menentukan kehadiran fruktosa, glukosa, galaktosa, sukrosa, maltosa, laktosa dan jumlah kandungan gula. Profil gula dilakukan menggunakan HPLC dengan detektor indeks biasan (RI). Hasil kajian menunjukkan bahawa semua jenama mengandungi kandungan gula yang agak tinggi berbanding dengan label yang menyatakan kandungan aktifnya. Keputusan ini telah dijangkakan kerana penambahan gula dalam makanan tambahan untuk kanak-kanak memudahkan pengambilan. Pastil berperisa pic didapati mengandungi jumlah sukrosa paling banyak per pastil diikuti dengan gummies berperisa strawberi. Melalui kajian ini, kami mendapati bahawa perasa tertentu memerlukan lebih banyak kandungan gula berbanding yang lain. Penemuan ini memberikan maklumat tentang perlabelan keperluan kandungan gula yang lebih komprehensif dan bahan aktif dalam suplemen kesihatan.

 

Kata kunci:  suplemen kesihatan; gula; kanak-kanak, Malaysia, perisa

 

References

1.      Almoazen H. Chapter 4: Dosage forms and drug delivery systems. In the APhA complete review for pharmacy, 12th edition; The American Pharmacists Association, 2017.

2.      Moreira, M., and Sarraguça, M. (2017). How can oral paediatric formulations be improved? A challenge for the XXI Century. International Journal of Pharmaceutics, 590:119905.

3.      Batchelor, H. K., Marriott, J. F. (2015). Formulations for children: Problems and solutions. Brazilian Journal of Clinical Pharmacology, 79:405-418.

4.      Walsh, J., Ranmal, S. R, Ernes, T. B. and Liu, F. (2018). Patient acceptability, safety and access: A balancing act for selecting age-appropriate oral dosage forms for paediatric and geriatric populations. International Journal of Pharmaceutics, 536:547-562.

5.      Piccone, P., Rastelli, S. L., Pitti, P. (2011). Aroma release and sensory perception of fruit candies model systems. Procedia Food Sciences, 1:1509-1515.

6.      Amarra, M. S., Khor, G. L., Chan, P. (2016). Intake of added sugar in Malaysia: A review. Asia Pacific Journal Clinical Nutrition, 25:227-240.

7.      Kamaruddin F. (2021). Sugar intake and oral health - PORTAL MyHEALTH Available online: http://www.myhealth.gov.my/en/sugar-intake-and-oral-health/ [accessed on 10 February 2021].

8.      Campbell, E., Schlappal, A., Geller, E. and Castonguay, T. W. (2014). Chapter 19- fructose-induced hypertriglyceridemia: A review. In nutrition in the prevention and treatment of abdominal obesity. Academic Press: San Diego. 2014: pp. 197-205.

9.      Rippe, J. M. and Angelopoulos, T. J. (2015). Sugars and health controversies: What does the science say? Advances Nutrition, 6: 493S-503S.

10.   Johnson, R. K. and Yon, B. A. (2010). Weighing in on added sugars and health. Journal American Diet Association, 110:1296-1299.

11.   Clemens, R. A, Jones, J. M, Kern, M, Lee, S. Y., Mayhew, E. J., Slavin, J. L. and Zivanovic, S. (2016). Functionality of sugars in foods and health. Comprehensive Review Food Science and Food Safety, 15: 433-470.

12.   Chandrawanshi, M. J, Sakhare R. S, Nagoba S. N. and Bhalekar R. V. (2018). A review on medicated lozenges. World Journal Pharmaceutical Research, 8: 396-412.

13.   O’Brien, S. K, Malacova, E., Sherriff J. and Black, L. J. (2017). The prevalence and predictors of dietary supplement use in the Australian population. Nutrients, 9: 1154.

14.   Dwyer, J., Nahin, R. L., Rogers, G.T, Barnes, P. M., Jacques, P. M., Sempos, C. T. and Bailey, R. (2013). Prevalence and predictors of children's dietary supplement use: The 2007 national health interview survey. American Journal Clinical Nutrition, 97:1331-1337.

15.   Qato, D. M., Alexander, G. C, Guadamuz, J. S. and Lindau, S. T. (2018). Prevalence of dietary supplement use in US children and adolescents, 2003-2014. JAMA Pediatrics, 172:780.

16.   Del Balzo V, Vitiello V. and Germani A. (2014). A cross-sectional survey on dietary supplements consumption among Italian Teen-Agers. PLoS ONE, 9: e100508.

17.   Sichert-Hellert, W. and Kersting M. (2004). Vitamin and mineral supplement use in German children and adolescents between 1986 and 2003: Results of the DONALD study. Annual Nutritional Metabolism, 48: 414-419.

18.   Marjamaki, L., Rasanen, M., Uusitalo, L., Anohen, S., Veijola, R., Knip, M. and Virtanen, S. M. (2004). Use of vitamin D and other dietary supplements by Finnish children at the age of 2 and 3 years. International Journal of Vitamin Nutritional Research, 74:27-34.

19.   Kobayashi, E., Nishijima, C., Sato, Y., Umegaki, K. and Chiba, T. (2018). The prevalence of dietary supplement use among elementary, junior high, and high school students: A nationwide survey in Japan. Nutrients, 10:1176.

20.   Mori, N., Kubota, M., Hamada, S. and Nagai A. (2011). Prevalence and characterization of supplement use among healthy children and adolescents in an urban Japanese city. Health, 3:135-140.

21.   Yoon, J. Y., Park, H. A., Kang, J. H., Kim, K. W., Hur, Y. I., Park, J. J., Lee, R. and Lee, H. H. (2012). Prevalence of dietary supplement use in korean children and adolescents: Insights from Korea national health and nutrition examination survey 2007-2009. Journal Korean Medicine Sciences, 27:512-517.

22.   Sien, Y. P., Sahril, N., Mutalip, M. H. A., Zaki, N. A. M. and Ghaffar, S. A. (2014). Determinants of dietary supplements use among adolescents in Malaysia. Asia Pacific Journal Public Health, 26(5S): 36S-43S.

23.   Vennard, T. R., Ruosch, A. J., Wejrowski, S. M. and Ellingson, D. J. (2020). Sugar profile method by high-performance anion-exchange chromatography with pulsed amperometric detection in food, dietary supplements, pet food, and animal feeds: First action 2018.16. Journal AOAC International, 103(1):89-102.

24.   Tihomirova, K, Dalecka B. and Mezule L. (2016). Application of conventional HPLC RI technique for sugar analysis in hydrolysed hay. Agronomy Research, 14(5):1713-1719.

25.   Potter, N. N. and Hotchkiss, J. H. (1995). Confectionery and chocolate products. Food Science Text Series, 464-477.

26.   Soukoulis, C. and Tzia, C. (2018). Grape, raisin and sugarcane molasses as potential partial sucrose substitutes in chocolate ice cream: A feasibility study. International Dairy Journal, 76:18-29.

27.   Onwulata, C. I. and Holsinger, V. H. (1996). Rheology and thermal properties of syrupy composites of saccharides and milk fat. Journal of Food Lipids, 3(1): 43-57.

28.   Tagami, T., Ito, E., Kida, R., Hirose, K., Noda, T. and Ozeki, T. (2021). 3D printing of gummy drug formulations composed of gelatin and an HPMC-based hydrogel for pediatric use. International Journal of Pharmaceutics, 594: 120118.

29.   Wood, H. W. (1958). The identification of the sugar in gelatin. Journal Photographic Sciences, 6:170-175.

30.   Evans, E. W., Hayes, C., Palmer, C. A., Bermudez, O. I., Cohen, S. A. and Must, A. (2013). Dietary intake and severe early childhood caries in low-income, young children. Journal of the Academy of Nutrition and Dietetics, 113(8): 1057-1061.

31.   Folayan, M. O., Arije, O., El Tantawi, M., Kolawole, K. A., Obiyan, M., Arowolo, O. and Oziegbe, E. O. (2019). Association between early childhood caries and malnutrition in a sub-urban population in Nigeria. BMC Pediatrics, 19(1): 1-8.

32. National Pharmaceutical Regulatory Agency (NPRA) Product Classification Guideline - Drugs or Food Products (2021). Available online: https://npra.gov.my/index.php/en/classification-guideline/product-classification-guideline.html?highlight=WyJjbGFzc2lmaWNhdGlvbiIsIidjbGFzc2lmaWNhdGlvbiJd [accessed on 26 May 2021].

33.   Dickinson, A., Bonci, L., Boyon, N. and Franco, J. C. (2012). Dietitians use and recommend dietary supplements: Report of A survey. Nutrition Journal, 11:14.

34.   Goston, J. L. and Correia, M. I. T. D. (2010). Intake of nutritional supplements among people exercising in gyms and influencing factors. Nutrition, 26(6): 604-611.

35.   Abe-Matsumoto, L. T., Sampaio, G. R. and Bastos, D. H. M. (2018). Do the labels of Vitamin A, C, and E supplements reflect actual vitamin content in commercial supplements? Journal Food Composition Analysis, 72: 141-149.