Malaysian Journal of Analytical Sciences Vol 23 No 3 (2019): 390 - 400

HIDROGEL BERSIFAT PEKA TERHADAP RANGSANGAN SUHU UNTUK PENJERAPAN DAN PEMBEBASAN DADAH

(Hydrogel with Thermo-Responsive Behavior for Drug Adsorption and Release)

Teow Yeit Haan^1,2* and Kushalini Rames²

¹Research Centre for Sustainable Process Technology (CESPRO), Faculty of Engineering and Built Environment

²Chemical Engineering Programme, Faculty of Engineering and Built Environment

Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia

*Corresponding author: yh_teow@ukm.edu.my

Received: 22 April 2019; Accepted: 12 May 2019

Abstrak

Dalam kajian ini, hidrogel bersifat peka terhadap rangsangan suhu disintesis sebagai media penyampaian dadah. Prestasi hidrogel yang disintesis dikaji dengan menggunakan peratusan asid sitrik yang berbeza iaitu 5%, 10%, dan 15%. Penggunaan asid sitrik yang banyak membawa kepada ikatan yang kuat sesama polimer, seterusnya meningkatkan peratus transmisi kumpulan berfungsi O-H dan kehidrofilikan hidrogel. Maka, molekul aspirin yang mempunyai kumpulan berfungsi asid karboksilik bersifat polar akan lebih cenderung dijerap pada permukaan hidrogel yang disintesis dengan menggunakan 15% asid sitrik melalui ikatan hidrogen. Di samping itu, rangkaian polimer yang padat lebih peka terhadap rangsangan suhu. Oleh itu, hidrogel yang disintesis dengan menggunakan 15% asid sitrik adalah lebih berkesan untuk membebaskan molekul aspirin yang dijerap padanya. Dalam kajian penjerapan dan pembebasan dadah yang dijalankan, keputusan yang tercapai didapati lebih menepati model Langmuir dan model Kinetik Pseudo pertama. Model Langmuir menyatakan bahawa penjerapan aspirin hanya melibatkan satu lapisan di permukaan hidrogel. Setelah penjerapan berlaku pada sesuatu tempat di permukaaan hidrogel, tiada lagi penjerapan berterusan yang akan berlaku. Manakala model Kinetik Pseudo pertama menerangkan bahawa penjerapan yang berlaku adalah melalui mekanisme fizikal, molekul aspirin akan dijerap atas permukaan hidrogel tanpa berlakunya tindak balas dengan permukaan hidrogel.

Kata kunci: hidrogel, rangsangan suhu, penjerapan dadah, pembebasan dadah, suhu badan

Abstract

In this study, hydrogel with thermo-responsive behavior was synthesized as a medium for drug delivery. Performance of synthesized hydrogel was studied using a different percentage of citric acid at 5%, 10%, and 15%. The use of a large amount of citric acid leads to a strong polymer bond, thus increasing the percentage of O-H functional group subsenquently hydrophilicity of hydrogel. Therefore, polar aspirin molecules with functional group of carboxylic acid are more likely to be adsorbed on the surface of the hydrogel synthesized using 15% citric acid via hydrogen bonding. In addition, dense polymer chain is more responsive to temperature change. Hence, hydrogel synthesized using 15% citric acid is more effective to release the adsorbed aspirin molecules. In the drug adsorption and release study, the results achieved were fitted closely with the Langmuir model and the Pseudo first kinetic model. Langmuir model implied that aspirin adsorption involves only one layer on the surface of the hydrogel. After adsorption occurs on the hydrogel surface, no further assorption will occur. While the Pseudo first kinetic model supported that the adsorption occurs through physical mechanisms where aspirin molecules will be adsorbed on the surface of the hydrogel without the occurrence of reaction.

Keywords: hydrogel, thermo-responsive, drug adsorption, drug release, body temperature

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