Malaysian
Journal of Analytical Sciences Vol 23 No 2 (2019): 212 - 218
DOI:
10.17576/mjas-2019-2302-05
ELECTROSPUN
POLY (VINYL ALCOHOL) NANOFIBERS DOPED WITH MESOPOROUS SILICA NANOPARTICLES FOR
CONTROLLED RELEASE OF HYDROPHILIC MODEL DRUG
(Elektrospun Poli(Vinil Alkohol) Nanofiber Didopkan Dengan
Silika Nanopartikel Berliang Meso untuk Perlepasan Terkawal Model Dadah
Hidrofilik)
Nur Izzah Md
Fadilah1, Haslina Ahmad1,2*, Mohd Firdaus Abd Rahman3,
Norizah Abdul Rahman2
1Integrated Chemical Biophysics Research
2Department of Chemistry, Faculty of Science
3Institute of
Advanced Technology
Universiti Putra
Malaysia, 43400 UPM Serdang, Selangor, Malaysia
*Corresponding
author: haslina_ahmad@upm.edu.my
Received: 19
August 2018; Accepted: 10 March 2019
Abstract
Nanofiber materials have often been
reported as transporters for clinical drugs but face the limitation of burst
releasing the drugs. Therefore, mesoporous silica nanoparticles (MSNs) have
raised much interest to be used in drug delivery system because of their large
pore volume and high surface area. In this study, nanofiber drug delivery
system based on poly(vinyl alcohol) (PVA) loaded with novel ionic liquid
templated MSNs were successfully prepared by the electrospinning method. The
composite fiber mat was designed for the prolonged and sustained release of
drug. MSNs were synthesized by co-condensation method with average particles
size of ~70 nm and then loaded with hydrophilic model drug methylene blue (MB).
The effect incorporation of MB-loaded MSNs into the polymer solution to form
fibrous structure was investigated. Uniform PVA/MB nanofiber mat was also
produced as controls. The morphologies of nanoparticles and composite nanofiber
were characterized by field emission scanning electron microscope (FESEM).
After electrospinning, electron microscope revealed that MSNs were randomly
distributed in the regions of nanofiber. Drug release profiles of MB from MSNs
and electrospun mats were evaluated. The results indicated that adsorption of
model drug MB into MSNs and incorporation them into nanofiber are effective way
of minimizing burst release of drug. Sustained delivery was achieved with
controllable release during the 120h releasing period
Keywords:
poly(vinyl alcohol), mesoporous silica
nanoparticles, nanofiber, electrospinning, drug delivery
Abstrak
Bahan
nanofiber sering dilaporkan sebagai penghantar untuk ubat-ubat klinikal tetapi
ia menghadapi limit batasan dalam melepaskan ubat secara pecah. Oleh itu, silika
nanopartikel berliang-meso (SMN) telah menimbulkan tarikan untuk digunakan
dalam sistem penghantaran ubat-ubat kerana memiliki isipadu liang yang besar
dan kawasan permukaan yang tinggi. Dalam kajian ini, sistem penghantaran ubat
iaitu nanofiber yang berdasarkan poli(vinil alkohol) (PVA) dimuatkan bersama
SMN cecair ionik baru telah berjaya disediakan melalui kaedah putaran elektro.
Komposit tikar fiber telah direka untuk pembebasan ubat yang berpanjangan dan
berterusan. SMN telah disintesis oleh kaedah pemeluwapan bersama dengan purata
saiz partikel ~70 nm dan kemudian, dimuatkan dengan model hidrofilik ubat iaitu
metilina biru (MB). Kesan penggabungan BM-SMN ke dalam polimer untuk membentuk
struktur fiber telah dikaji. Nanofiber PVA/BM yang seragam juga dihasilkan
sebagai kawalan. Morfologi nanopartikel dan komposit nanofiber telah dicirikan
oleh mikroskop elektron pengimbasan pelepasan medan (MMEPP). Selepas putaran elektro,
mikroskop elektron mendedahkan bahawa SMN berada secara rawak di dalam
nanofiber. Profil pembebasan ubat BM dari SMN dan tikar putaran elektro telah
dinilai. Keputusan menunjukkan bahawa penyerapan model ubat BM ke dalam SMN dan
seterusnya memasukkannya ke nanofiber adalah cara yang berkesan untuk
meminimumkan pembebasan ubat secara pecah. Penghantaran yang berterusan telah
dicapai dengan pembebasan yang dapat dikawal dalam tempoh 120 jam.
Kata kunci: poli(vinil alkohol), silika nanopartikel berliang-meso, nanofiber, elektrospining,
penghantaran ubat
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