Malaysian Journal of Analytical Sciences Vol 21 No 5 (2017): 1143 - 1150

DOI: https://doi.org/10.17576/mjas-2017-2105-17

 

 

 

SYNTHESIS AND ANTIBACTERIAL STUDY OF ORGANOTIN(IV) COMPLEXES CONTAINING HYDRAZINOPYRIDINE LIGAND

 

(Sintesis dan Kajian Antibakteria Kompleks Organostanum(IV) yang Mengandungi Ligan Hidrazinopiridin)

 

          Dayang Norafizan A. Chee*, Monica Lulo Rodis, Norziah Saat, Zainab Ngaini, Ainaa Nadiah Abdul Halim

 

Department of Chemistry, Faculty of Resource Science and Technology,

Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

 

*Corresponding author:  dnorafizan@unimas.my

 

 

Received: 21 August 2016; Accepted: 27 July 2017

 

 

Abstract

Nowadays, the studies on organotin(IV) complexes with hydrazone ligand become more interesting due to their potential in various applications including medicinal area. In our recent studies, four new organotin(IV) complexes MeSnCl₂(C₁₂H₁₂N₄) (2), BuSnCl₂(C₁₂H₁₂N₄) (3), PhSnCl₂(C₁₂H₁₂N₄) (4) and Ph₂SnCl(C₁₂H₁₂N₄) (5) were synthesized by the direct reaction of methyl-2-pyridylketone-2-hydrazinopyridine ligand (1) and organotin(IV) chloride(s) in absolute methanol. These complexes have been characterized by UV-Visible, FT-IR, ¹H and ¹³C NMR spectroscopies. All of the synthesized compounds were screened for antibacterial activity against Escherichia coli and Staphylococcus aureus. However, the complexes showed weak activity against the bacteria compared to the free ligand.

 

Keywords:  hydrazone ligand, spectral studies, coordination, biological potential

 

Abstrak

Pada masa ini, kajian tentang kompleks organostanum(IV) dengan ligan hidrazon semakin menarik kerana sangat potensinya dalam banyak aplikasi termasuk bidang perubatan. Dalam kajian ini, empat organostanum(IV) kompleks iaitu MeSnCl₂(C₁₂H₁₂N₄) (2), BuSnCl₂(C₁₂H₁₂N₄) (3), PhSnCl₂(C₁₂H₁₂N₄) (4) dan Ph₂SnCl(C₁₂H₁₂N₄) (5) telah disintesis melalui tindak balas terus metil-2-piridilketon-2-hidrazinopiridin ligan dan organostanum(IV) klorida di dalam metanol. Kesemua kompleks telah dicirikan oleh kajian spektrum UV-nampak, FTIR, ¹H dan ¹³C RMN. Semua sebatian yang disintesis telah diuji untuk aktiviti antibakteria terhadap Escherichia coli dan Staphylococcus aureus. Walaubagaimanapun, kompleks menunjukkan aktiviti yang agak lemah menentang bakteria berbanding ligan bebas.

 

Kata kunci:  ligan hidrazon, kajian spektra, koordinasi, potensi biologi

 

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