Malaysian Journal of Analytical Sciences Vol 21 No 5 (2017): 1151 - 1155

DOI: https://doi.org/10.17576/mjas-2017-2105-18

 

 

 

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL PROPERTIES OF COPPER(II) COMPLEX OF HETEROCYCLIC LIGANDS

 

(Sintesis, Pencirian dan Ciri Antimikrob Kuprum(II) Kompleks dengan Ligan Heterosiklik)

 

Rabuyah Ni*, Mohammad Isa Mohamadin, Vivien Jong Yi Mian

 

Faculty of Applied Sciences,

Universiti Teknologi MARA, Kampus Samarahan 2, 94300 Kota Samarahan, Sarawak, Malaysia

 

*Corresponding author:  abuyani2201@gmail.com

 

 

Received: 21 August 2016; Accepted: 27 July 2017

 

 

Abstract

Copper(II)-b-mangostin complex was prepared by 2:1 molar reaction of ligand, b-mangostin and copper(II) acetate in one-pot reaction. The resulting complex, [CuL₂(H₂O)₂] has been characterized by using spectroscopic techniques. Ligand and its metal complex were tested against Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumonia and Salmonella pneumoniae bacteria to assess on their antibacterial properties using Minimum Inhibitory Concentrations (MICs) and Minimum Bactericidal Concentrations (MBCs) method. The UV-Vis result showed that the complex has an octahedral geometry. The general formula [ML₂(H₂O)₂], in which L = b-mangostin, is determined from UV-Vis, FTIR and CHNS data.  Ligands were completely inactive against bacteria whereas the copper(II) b-mangostin complex has significant action on bacteria, indicating that it has a good potential as bactericide.

 

Keywords:  b-mangostin, copper(II) complex, antimicrobial, xanthones

 

Abstrak

Kompleks kuprum(II)-b-mangostin disediakan dengan nisbah 2:1 mol antara ligand, b-mangostin dan kuprum asetat dalam tindak balas satu-bekas. Kompleks yang dihasilkan, [CuL₂(H₂O)₂] dicirikan dengan menggunakan teknik spektroskopik. Ligan dan logam kompleks diuji ke atas bakteria Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumonia and Salmonella pneumoniae untuk menilai tindak balas bakteria menggunakan kaedah Kepekatan Perencatan Minimum (KPM) dan kaedah Kepekatan Bakteria Minimum (KBM). Keputusan UV-Vis menunjukkan kompleks mempunyai geometri oktahedron. Formula umum [ML₂(H₂O)₂], yang mana L = b-mangostin ditentukan dari data UV-Vis, FTIR dan CHNS. Ligand sepenuhnya tidak aktif ke atas bakteria, manakala komplex kuprum(II) b-mangostin memberikan tindak balas yang signifikan ke atas bakteria, menunjukkan ia mempunyai potensi yang baik sebagai bactericide.

 

Kata kunci:  b-mangostin, kuprum(II) kompleks, antimikrob, xanthones

 

References

1.       Grazul, M., and Budzisc, E. (2009). Biological activity of metal ions complexes of chromones, coumarines and flavones. Coordination Chemistry Review, 253: 2588 – 2598.

2.       Panhwar, Q.K., Memon S. and Bhanger, M.I. (2010). Synthesis, characterisation, spectroscopic and antioxidant studies of Cu(II)-morin Complex. Journal of Molecular Structure, 967: 47 – 53.

3.       Aisha, A. F. A., Abu-Salah, K. M., Ismail, Z. and Abdul Majid, A. M. S. (2013). Determination of total xanthones in Garcinia mangostana fruit rind extracts by ultraviolet (UV) spectrophotometry. Journal of Medicinal Plant Research, 7(1): 29 – 35.

4.       Yoshwathana, N. and Estiaghi, M. N. (2015). Optimization of subcritical ethanol extraction for xanthone from mangosteen pericarp. International Journal of Chemical Engineering and Application, 6(2): 115 – 119.

5.       Sylvain V. T. Sob, H. K., Wabo, A. T., Tchinda, P., Tane, B. T. and Ngadjui, Y. Y. (2010). Anthraquinones, sterols, triterpenoids and xanthones from Cassia obtusifolia. Biochemical Systematics and Ecology, 38: 342 – 345.

6.       Shagutfa, and Ahmad, I. (2016). Recent insight into the biological activities of synthetic xanthone derivatives, European Journal of Medicinal Chemistry, 116: 267 – 280.

7.       Shen, R., Wang, P. and Tang, N. (2009). Synthesis, crystal structure, DNA-binding properties and cytotoxic activity of the copper(II) complex involving xanthone. Journal of Fluorescence, 19: 1073 –1082.

8.       Wang, H.F., Shen, R. and Tang, N. (2009). Synthesis and characterization of the Zn(II) and Cu(II) piperidinyl isoeuxanthone complexes: DNA-binding and cytotoxic activity. European Journal of Medicinal Chemistry, 44: 4509 – 4515.

9.       Angia, V., Bakhtiar, A. and Arbain, D. (2015). The isolation of xanthones from trunk latex of Garcinia mangostana Linn. and their antimicrobial activities. Indonesian Journal Chemistry, 15(2): 187 – 193.

10.    Fei, X., Jo, M, Lee, B., Han, S.B., Lee, K., Jung, J.K., Seo, S.Y. and Kwak, Y.S. (2014). Synthesis of xanthone derivatives based on a-mangostin and their biological evaluation for anticancer agents. Bioorganic & Medicinal Chemistry Letters, 21: 2062 – 2065.

11.    Bukhari, S. B., Memon, S., Tahir, M. M. and Bhanger M. I. (2009). Synthesis, charaterisation and antioxidant activity copper-quercetin complex. Spectrochimica Acta, 71: 1901 – 1906.

12.    Destandau, E., Toribio, A., Lafosse, M., Pecher, V., Lamy, C. and Andre, P. (2009). Centrifugal partition chromatography directly interfaced with mass spectrometry for the fast screening and fractionation of major xanthones in Garcinia mangostana. Journal of Chromatography A, 1216: 1390 – 1394.

13.    Ee, G. C. L., Daud, S., Taufiq Yap, Y. H., Ismail, N. H. and Rahmani, M. (2006). Xanthones from Garcinia mangostana (Guttiferae). Natural Product Research, 20: 1067 – 1073.

14.    Gopalakrishnan, G., Banumathi, B. and Suresh, G. (1997). Evaluation of the antifungal activity of natural xantones from Garcinia mangostana and their synthetic derivatives. Journal Natural Product, 60: 519 – 524.

15.    Sen, A. K. Sarkar, K. K., Mazumder, P. C., Banerji, N., Uusvuori, R. and Hase, T. A. (1982). The structure of garcinones A, B and C: Three new xanthones from Garcinia mangostana. Phytochemistry, 21:1747 – 1750.

16.    Al-Massarani, S. M., El Gamal, A. A., Al-Musayeib, N. M., Mothana, R. A., Basudan, O. A., Al-Rehaily, A. J., Farag, M., Assaf, M. H., El Tahir, K. and Maes, L. (2013). Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and a-mangostin, Its major xanthone derivative. Molecules, 18: 10599 – 10608.

17.    Syam, S., Bustaman, A. Abdullah, R., Sukari, M. A, Hashim, N. M., Yahayu, M., Hassandarvish, P. and Abselwaheb, S. I. (2014). Cytotoxic and oral acute toxicity studies of b-mangostin isolated from Cratoxylum arborescens. Phcog Journal, 6: 47 – 56.

18.    Yousef, T. A., Abu El-Raesh, G. M, Al-jahdali, M. and El-Rakhawy, E. R. (2014). Synthesis, spectral characterization and biological evaluation of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes with thiosemicarbazone ending by pyrazole and pyridyl rings. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 129: 163 – 172.

19.    Farhan, S. A. (2013). Study on the interaction of copper(II) complex of morin and its antimicrobial effect. International Journal Chemistry of Sciences, 11(3): 1248 – 1255.