Malaysian Journal of Analytical Sciences Vol 23 No 2 (2019): 255 - 262

Synthesis and characterisation of nanohybrid anti-hypertensive drug, captopril intercalated into zinc–Aluminium layered double hydroxide

(Sintesis dan Pencirian Nanohibrid Ubat Anti-Hipertensi, Captopril Tersisip ke dalam Zink-Aluminium Hidroksida Berlapis Ganda)

Zaemah Jubri¹*, Siti Halimah Sarijo², Monica Limau Anak Jadam¹

¹Centre for Advanced Materials,

Universiti Tenaga Nasional, 43000 Kajang, Selangor, Malaysia

²Faculty of Applied Sciences,

Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

*Corresponding author: zaemah@uniten.edu.my

Received: 19 August 2018; Accepted: 10 March 2019

Abstract

Captopril (CPL), an anti-hypertensive drug was intercalated into the interlayer spaces of zinc–aluminium layered double hydroxide (ZLDH) for the formation of zinc–aluminium–captopril (ZCPL) hybrid nanocomposite material by self-assembly method. The concentration of CPL used was 0.08 M with pH 7.5 in a constant 3:1 molar ratio of zinc (Zn) to aluminium (Al) in the mother liquor. As a result of the successful intercalation of CPL, powder X-ray diffraction pattern (PXRD) shows the basal spacing increased from 8.90 Å in ZLDH to 9.69 Å in the ZCPL nanohybrid material. Fourier transform infrared (FTIR) spectroscopy study shows the intercalated compound of ZCPL resembled the spectra of ZLDH and CPL, thus indicating the presence of both functional groups in ZCPL spectra. CHNS analysis shows the ZCPL nanohybrid material contains 30.63% (w/w) of CPL which was calculated based on the percentage of carbon in the sample. It was also found that the BET surface area increased from 1.7 m²/g in ZLDH to 10.9 m²/g in ZCPL. The pore texture of the resulting material was also changed as the result of the intercalation and the expansion of the basal spacing during the formation of the layered intercalated ZCPL nanohybrid material.

Keywords: captopril, anti-hypertensive drug, intercalation, layered double hydroxide, nanocomposite

Abstrak

Captopril (CPL) iaitu ubat anti-hipertensi telah berjaya disisipkan ke dalam ruang antara lapis hidroksida berlapis ganda bagi pembentukan bahan hibrid ZCPL nanokomposit melalui kaedah pembentukan sendiri. Kepekatan CPL yang digunakan adalah 0.08M dan pH 7.5 dengan nisbah kepekatan tetap Zn : Al adalah 3 : 1 dalam larutan akueous. Penyisipan anion captopril dapat ditentukan dari pengembangan jarak basal PXRD daripada 8.90 Å bagi zink-aluminium hidroksida berlapis ganda (ZLDH) kepada 9.69Å bagi bahan nanohibrid ZCPL. Analisis inframerah transformasi Fourier (FTIR) menunjukkan kehadiran gabungan kumpulan berfungsi bagi ZLDH dan CPL kelihatan pada spektra ZCPL. Ini membuktikan CPL telah berjaya disisipkan di antara ruang hidroksida berlapis ganda bagi pembentukan bahan nanokomposit tersebut. Analisis CHNS menunjukkan bahan nanohibrid ZCPL mengandungi CPL dengan peratusan 30.63 % (w/w) yang ditentukan melalui pengiraan peratusan karbon di dalam sampel nanohibrid ZCPL. Luas permukaan BET telah meningkat daripada 1.7 m²/g kepada 10.9 m²/g masing-masing bagi ZLDH dan ZCPL. Struktur liang bahan nanohibrid yang terhasil juga telah berubah disebabkan penyisipan captopril telah mengembangkan jarak basal, begitu juga dengan pembentukan liang yang lebih besar berlaku hasil dari pembentukan bahan nanohibrid, ZCPL.

Kata kunci: captopril, ubat anti-hipertensi, sisipan, hidroksida berlapis ganda, nanokomposit

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