Malaysian
Journal of Analytical Sciences Vol 21 No 6 (2017): 1266 - 1275
DOI:
10.17576/mjas-2017-2106-08
POTENTIOMETRIC STUDY OF RHENIUM(V) COMPLEX
FORMATION WITH AZATHIOPRINE AND CEFTRIAXONE
(Kajian Potentiometri
Penghasilan Kompleks Rhenium(V) dengan Azatioprina dan Ceftriaxon)
Gamal Abdelaziz
Hussein Gouda 1*, Gomaa Abdelgawad Mohammed Ali 1, 2
1Chemistry Department, Faculty of
Science,
Al-Azhar
University, 71524 Assiut, Egypt
2Faculty of Industrial Sciences &
Technology,
Universiti
Malaysia Pahang, Gambang, 26300 Kuantan, Malaysia
*Corresponding author: ggouda73@mail.ru
Received: 3
March 2017; Accepted: 17 September 2017
Abstract
The behavior of complex formation of Re(V) metal ion with
azathioprine (AZ) and ceftriaxone (CE) as medicinal drugs has been investigated
potentiometrically in 0.3 M hydrochloric acid. The stability constant of the prepared
complexes has been determined and calculated at various temperatures. The
obtained results showed that Re(V)-AZ system showed the
formation 1:2, 1:3 and 1:4 complexes, while Re(V)-CE showed only 1:1 and
1:2 complexes. The complex
formation suggests a successive displacement of the chloride molecules from the
coordination sphere of the central ion by the AZ ligand. In addition,
the effect of temperature on the complexes formation of Re(V) with AZ and CE
was investigated. The entropy and enthalpy changes showed a favorable and
exothermic process, respectively. The kinetic parameters of the formation
complex process were calculated and discussed.
Keywords: rhenium(V), drugs, potentiometry, complex formation,
stability constant
Abstrak
Tingkah laku penghasilan
kompleks ion logam Re(V) dengan azatioprina (AZ) dan ceftriaxon (CE) sebagai
ubat – ubatan telah dikaji secara potentiometri dalam 0.3 M asid hidroklorik.
Pemalar kestabilan terhadap kompleks yang dihasilkan telah ditentukan dan
dikira pada pelbagai tahap suhu. Hasil yang diperoleh menunjukkan bahawa sistem
Re(V)-AZ mempamerkan penghasilan kompleks 1:2, 1:3 dan 1:4, sementara Re(V)-CE
mempamerkan hanya kompleks 1:1 dan 1:2. Penghasilan kompleks mencadangkan satu
anjakan molekul klorida berturut-turut dari lingkungan koordinasi ion tengah
oleh ligan AZ. Di samping itu, kesan suhu pada pembentukan kompleks Re(V)
dengan AZ dan CE telah dikaji. Perubahan entropi dan entalpi menunjukkan proses
yang baik dan eksotermik. Parameter kinetik proses penghasilan kompleks turut
dikira dan dibincangkan.
Kata kunci: rhenium(V), ubat,
potentiometri, penghasilan kompleks, pemalar kestabilan
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