Malaysian Journal of Analytical Sciences Vol 21 No 6 (2017): 1219 - 1225

SYNTHESIS OF BENZOTHIAZOLE DERIVATIVES USING ULTRASONIC PROBE IRRADIATION

(Sintesis Terbitan Benzothiazola Dengan Menggunakan Prob Penyinaran Ultrasonik)

Su-Yin Kan¹, Wei Sern Yiong², Fu Siong Julius Yong³, Poh Wai Chia^2,
3*

¹Faculty of Health Sciences,

Universiti Sultan Zainal Abidin, 21030 Kuala Nerus, Malaysia

²School of Marine and Environmental Science

³Institute Marine Biotechnology

Universiti Malaysia Terengganu, 21030 Kuala Nerus, Malaysia

*Corresponding author: pohwai@umt.edu.my

Received: 14 June 2017; Accepted: 17 September 2017

Abstract

Benzothiazoles are an important class of pharmaceutical drug with various therapeutic activities. In this work, an efficient and eco-friendly method of synthesizing of benzothiazole derivatives via ultrasonic probe irradiation was described here. Through the improved protocol, the benzothiazole derivatives were prepared with various benzaldehyde and 2-aminothiophenol. The yields were found to be in moderate to good yields, ranging from 65 – 83%. Among the advantages of this procedure as compared to the conventional methods of synthesizing benzothiazoles include simplicity in the procedure, solvent-, catalyst- free reaction and the improved protocol afforded compounds (4a-4i) within 20 minutes at room temperature. The current improved protocol could be extended for the synthesis of other bioactive heterocyclic compounds in future work.

Keywords: benzothiazole, ultrasound, solvent-free, catalyst-free.

Abstrak

Benzotiazola adalah kelas ubat farmaseutikal yang penting dengan pelbagai aktiviti terapeutik. Dalam kajian ini, satu kaedah yang efisien dan mesra alam bagi sintesis terbitan benzotiazola dengan menggunakan prob penyinaran ultrasonik dibincangkan. Melalui kaedah yang ditambahbaik, terbitan benzotiazola dapat disediakan melalui pelbagai benzaldehid dan 2-aminatiofenol. Peratusan hasil produk didapati dari sederhana hingga baik, iaitu antara julat 65 – 83%. Kelebihan protokol ini berbanding dengan kaedah – kaedah konvensional bagi sintesis terbitan benzatiazola, termasuk prosedur yang mudah, tanpa penggunaan pelarut, tanpa pemangkin dan protokol yang ditambahbaik menghasilkan sebatian (4a-4i) dalam masa 20 minit pada suhu bilik. Kaedah yang ditambahbaik kini boleh diperluaskan untuk sintesis sebatian heterosiklik bioaktif lain dalam kajian masa hadapan.

Kata kunci: benzotiazola, prob penyinaran ultrasonik, tanpa pengunaan pelarut, tanpa penggunaan pemangkin

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