Malaysian Journal of Analytical Sciences Vol 21 No 5 (2017): 1203 - 1209

DOI: https://doi.org/10.17576/mjas-2017-2105-25

 

 

 

ONE-POT MANNICH BASE SYNTHESIS USING TASK SPECIFIC PROTIC IONIC LIQUIDS

 

(Sintesis Bes Mannich Tunggal Menggunakan Cecair Ionik Terkhusus)

 

Sabahat Sardar*, Cecilia Devi Wilfred, Jean Marc Leveque

 

Fundamental and Applied Sciences

Universiti Teknologi PETRONAS, Teronoh, Perak, Malaysia

 

*Corresponding author:  sba.qau@gmail.com

 

 

Received: 21 August 2016; Accepted: 27 July 2017

 

 

Abstract

Three-component Mannich reaction of ketones, aromatic aldehydes and aromatic amines was catalyzed by four Bronsted acidic ionic liquids comprising of iodide and borate at room temperature. Ionic liquid have been used as catalyst and solvent to produce some Mannich bases in high yield (75%) and shorter reaction time (20 minutes). Work up has been facilitated by simple extraction with water to recover ionic liquid for recycling up to four times without any significant loss in activity.

 

Keywords:  Mannich bases, Bronsted acidic ionic liquids, 1-methylimidazole, 1,3-propane sultone, 1,4-butane sultone

 

Abstrak

Tindak balas tiga komponen Mannich iaitu keton, aldehid aromatik dan amina aromatik telah dimangkinkan oleh empat cecair ionik Bronsted berasid yang terdiri daripada iodida dan borat pada suhu bilik. Cecair ionik telah digunakan sebagai pemangkin dan pelarut untuk menghasilkan beberapa bes Mannich dengan hasil yang tinggi (75%) dan masa tindak balas yang lebih pendek (20 minit). Kerja pengekstrakan telah dipermudah dengan menggunakan air dan boleh dikitar semula sehingga empat kali tanpa sebarang kehilangan aktiviti yang penting.

 

Kata kunci:  bes Mannich, asid Bronsted cecair ionik, 1-metilimidazol, 1,3-propana sulton, 1,4-butana sulton

 

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