Malays. J. Anal. Sci. Volume 30 Number 1 (2026): 1736

 

Review Article

 

A mini review on the morphology, phytochemical constituents and selected biological activities of Mikania micrantha Kunth (asteraceae)

 

Norhayati Yusuf1,2, Nurul Huda Abdul Wahab1,3 and Asnuzilawati Asari1,3*

 

1Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia.

2Biology Security and Sustainability Research Interest Group, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia.

3Advanced Nano Materials (ANoMA) Research Group, Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia

 

*Corresponding author: asnu@umt.edu.my

 

Abstract

Mikania micrantha Kunth (Asteraceae) is a well-known fast-growing invasive climber that is widely distributed across tropical and subtropical regions. Although recognised as one of the world’s most destructive alien weeds, M. micrantha has become the focus of increasing research interest for its phytochemical constituents and pharmacological potential. This mini review highlights current knowledge on its morphology, phytochemical constituents and selected biological activities. Many bioactive compounds, including flavonoids, phenolics, sesquiterpene lactones and alkaloids were reported to contribute to diverse biological properties, such as antioxidant, antimicrobial, anti-tumour and allelopathic effects. These findings demonstrated the dual identity of M. micrantha as both a major ecological threat and a promising source of novel therapeutic agents. A deeper understanding of its phytochemistry and bioactivity may help transform this invasive species into a sustainable resource for drug discovery and value-added applications.

 

Keywords: Mikania micrantha, invasive weed, phytoconstituents, pharmacological activities, therapeutic potential



References

1.    Sathi, S., Kalyan, M.S. and Habibur Rahman, C. (2015). Anato-pharmacognostic studies of Mikania micrantha Kunth: A promising medicinal climber of the family of Asteraceae. International Journal of Research Ayurveda Pharmacology, 6(6): 773-779.

2.    Sheam, M.M., Haque, Z., and Nain, Z. (2020). Towards the antimicrobial, therapeutic and invasive properties of Mikania micrantha Kunth: A brief overview. Journal of Advanced Biotechnology and Experimental Therapeutics, 3(2): 92-101.

3.    Day, M.D., Clements, D.R., Gile, C., Senaratne, W.K.A.D., Shen, S. Weston, L.A. and Zhang, F. (2016). Pacific Science, 70(3): 257-285.

4.    Ardianto, A., Munarsih, D., Rahayu, L.N., Aslam, M.M., Aditya, M.F., Estiningsih, D., Fatmawati, A. and Saputro, P.H. (2022). Screening and antidiarrheal activity testing of Sembung Rambat (Mikania micrantha) leaves. Macedonian Journal of Medical Sciences, 10(T8):194-199.

5.    Sahu, D.S., Dutta, S., Das, M., Debnath, S.K., Barik, L. and Hazra, J. (2019). Pharmacognostical and phytochemical profiling of Tarulata Patra (Mikania micrantha Kunth leaves). Paripex - Indian Journal of Research, 8(9): 4-7.

6.    Cheng, Q., Lyu, B., Zhang, Z., Huang, Y. and Wang. (2024). Research on the antipruritic active ingredients of Mikania micrantha. Fitoterapia, 174: 105837.

7.    Lou, T., Xu, Q., Tan, Y., Liu, S., Zhang, S., Zhang, Y., Jiang, F., and Tan, J. (2023). Two new germacrane sesquiterpenoids from the inflorescences of Mikania micrantha. Phytochemistry Letters, 54: 141-145.

8.    Clout, M., and De Poorter, M. (2005). International initiatives against invasive alien species. Weed Technology, 19(3): 523-7.

9.    Khadka, A. (2017). Assessment of the perceived effects and management challenges of Mikania micrantha invasion in Chitwan National Park buffer zone community forest, Nepal. Heliyon, 3(4): e00289.

10. Dong, L.M., Jia, X.C., Luo, Q.W., Zhang, Q., Luo, B., Liu, W.B., Zhang, X., Xu, Q.L. and Tan, J.W. (2017). Phenolics from Mikania micrantha and their antioxidant activity. Molecules. 22(7):1140.

11. Asia-Pacific Forest Invasive Species Network. (2025). Mikania micrantha: Asia-Pacific Forest Invasive Species Network Fact Sheet. FAO. Retrieved from https://www.fao.org/forestry-fao/13376-05d702161c15b1e3defa6bf9c8e6c4f82. pdf

12. USDA. (2025). Taxon:  Mikania micrantha Kunth. Retrieved from https://npgsweb.ars-grin.gov/gringlobal/taxon/taxonomydetail?id=316383. Retrieved on 16th Dec 2025.

13. Bora, A.R. and Babu, D.S. (2021). Biology and distribution of the invasive alien weed Mikania micrantha-A review. International Journal Current Microbiology Applied Sciences, 10(3): 2044-2049.

14. Zhang, M.X., Ling, B., Chen, S.Y., Liang, G.W. and Pang, X.F. (2004). Repellent and oviposition deterrent activities of the essential oil from Mikania micrantha and its compounds on Plutella xylostella. Insect Sciences,  11: 37-45.

15. Poudel, M., Adhikari, P. and Thapa, K. (2019). Biology and control methods of the alien invasive weed Mikania micrantha: A review. Environmental Contaminants Reviews. 2(2): 6-12.

16. Zhang, D., Zhao, M., Li, Q., Guo, J., Zhang, H., Liu, W. and Sun, W. (2024). Mikania micrantha stimulates microbial functional groups in soil: A-mini review. Rhizosphere, 30:100919.

17. Hong, L., Shen, H., Ye, W., Cao, H. and Wang, Z. (2008). Secondary pollen presentation and style morphology in the invasive weed Mikania micrantha in South China. Botanical Studies, 49: 253-260.

18. Honório, A, C., Quaresma, A. S., Oliveira, C. T. and Bezerra Loiola, M. I. (2019). Flora of Ceará, Brazil: Mikania (Asteraceae: Eupatorieae). Rodriguésia, 70: e02952017.

19. Vikram, P., Chiruvella, K.K., Ripain, I.H. and Arifullah, M. (2014). A recent review on phytochemical constituents and medicinal properties of kesum (Polygonum minus Huds.). Asian Pacific Journal Tropical Biomedicine, 4(6): 430-5. 

20. Zhang, J., Netzel, M. E., Pengelly, A., Sivakumar, D., and Sultanbawa, Y. (2023). A review of phytochemicals and bioactive properties in the Proteaceae Family: A promising source of functional food. Antioxidants, 12(11): 1952.

21. Devkota, A. and Sahu, A. (2016). Antimicrobial activities and phytochemical screening of leaf extract of Mikania micrantha H.B.K. Journal Nature History Museum, 30: 274-286.

22. Sumantri, I.B., Wahyuni, H.S. and Mustanti, L.F. (2020). Total phenolic, total flavonoid and phytochemical screening by FTIR spectroscopy of standardized extract of Mikania micrantha leaf. Pharmacognosy Journal, 12(6): 1395-1401.

23. Yasmin, L., Dhara, S., Samanta, D., Saha, D., Bag, A. and Ray, M. (2025). Impact of climate change on the phytochemical constituents and in-vitro bioactivity of Mikania micrantha Kunth leaf. Journal of Pharmacognosy and Phytochemistry, 14(1): 322-328. 

24. Li, A., Hou, X. and Wei, Y. (2018). Fast screening of flavonoids from switchgrass and Mikania micrantha by liquid chromatography hybrid-ion trap time-of-flight mass spectrometry. Analytical Methods, 10: 109-122.

25. Hassan, N., Halis, R. and Esa, N.M. (2020). Phytochemical of invasive plant: Mikania micrantha. International Journal of Agriculture. Forestry and Plantation, 10: 209-215.

26. Ibrahim, A., Shafie, N.H., Esa, N.M., Shafie, S.R., Bahari, H. and Zainal, N.H.M. (2024). Phytochemicals and proteomic profiling of ethyl acetate of M. micrantha extract treated hypercholesterolemic Rats. Malaysian Journal Medical Health Sciences, 20(4): 114-123.

27. Wei, X., Huang, H., Wu, P., Cao, H. and Ye. W. (2004). Phenolic constituents from Mikania micrantha. Biochemical Systematics and Ecology, 32: 1091-1096.

28. But, P.P.H., He, Z.D., Ma, S.C., Chan, Y.M., Shaw, P.C., Ye, W.C., and Jiang, R.W. (2009). Antiviral constituents against respiratory viruses from Mikania micrantha. Journal of Natural Products, 800542.

29. Li, Y., Shen, B.B., Li, J., Li, Y., Wang, X.X. and Cao, A.C. (2013). Antimicrobial potential and chemical constituent of Mikania micrantha HBK. African Journal Microbiological Research, 7: 2409-2415.

30. Li, Y., Li, J., Li, Y., Wang, X.X. and Cao, A.C. (2013). Antimicrobial constituents of the leaves of Mikania micrantha HB K. PLoS ONE. 8: e76725.

31. Ma, Q., Li, J., Wu, X., Wang, Z., Yang, X., Pan, W., Su, S. and Li, Y. (2020). New Germacrane-sesquiterpenoids from the leaves of Mikania micrantha Kunth. Phytochemistry Letters, 40: 49-52.

32. Dong, L.-M., Xu, Q.-L., Liu, S.-B., Zhang, S.-X., Liu, M.-F., Duan, J.-L. and Tan, J.-W. (2023). Germacrane sesquiterpene dilactones from Mikania micrantha and their antibacterial and cytotoxic activity. Molecules, 28052119. 

33. Bagchi, D., Bagchi, M., Stohs, S.J., Das, D.K., Ray, S.D., Kuszynski, C.A., Joshi S.S. and Pruess, H.G. (2000). Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology, 148(2-3): 187-197.

34. Jaitak, V., Sharma, K., Kalia, K., Kumar, N., Singh, H., Kaul, V. and Singh, B. (2010). Antioxidant activity of Potentilla fulgens: An alpine plant of western Himalaya. Journal of Food Composition and Analysis, 23(2): 142-147.

35. Czinner, E.,  Hagymasi, K.,  Blazovics, A., Kery, A., Szőke, É. and  Lemberkovics, E. (2001). The in vitro effect of Helichrysi flos on microsomal lipid peroxidation. Journal of Ethnopharmacology, 77(1): 31-35.

36. Khatun, R., Rashid, M., Khurshid Alam, A.H.M., Lee, I.K. and Abdur Rahman, M.A. (2020). Evaluation of comparative phenolic contents and antioxidant activity of Mikania Species available in Bangladesh. Frontiers in Science, 10(1): 1-6

37. Jayaprakash, G., Girennavar, B. and Patil, B.S. (2008). Radical scavenging activities of Rio Red grapefruits and Sour orange fruit extracts in different in vitro model systems. Bioresource Technology, 99(10): 4484–4494.

38. Litwinienko, G. and Ingold, K.U. (2003). Abnormal effects on hydrogen atom abstractions. The reactions of phenols with 2,2-diphenyl-1-picrylhydrazyl (DPPH•) in alcohols. Journal Organic Chemistry, 68: 3433–3438.

39. Foti, M.C. and Ruberto, G. (2000). Kinetic solvent effects on phenolic antioxidants determined by spectrophotometric measurements. Journal Agriculture Food Chemistry, 49: 342–348.

40. Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F. and Arcoraci, V. (2017). Oxidative stress: harms and benefits for human health. Oxidative Medicine Cellular Longevity, 2017: 8416763.

41. Ayala, A., Muñoz, M.F. and Argüelles, S. (2014). Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxidative Medicine Cellular Longevity, 2014:360438.

42. Higashi, Y. (2022). Roles of oxidative stress and inflammation in vascular endothelial dysfunction-related disease. Antioxidants (Basel), 11:1958.

43. Hong, Y., Boiti, A., Vallone, D., and Foulkes, N.S. (2024). Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution. Antioxidants, 13(3): 312.

44. Cui, C., Wang, Z., Su, Y. and Wang, T.  (2022). Antioxidant regulation and DNA methylation dynamics during Mikania micrantha seed germination under cold stress.  Frontier Plant Sciences, 13: 856527.

45. Wu, A.P., Yu, H., Gao, S.Q., Huang, Z.Y., He, W.M., Miao, S.L. and Dong, M. (2009). Differential below ground allelopathic effects of leaf and root of Mikania micrantha. Trees, 23: 11-17.

46. Zhang, G., Wang, C., Ren, X., Li, Z., Liu, C., Qiao, X., Shen, S., Zhang, F., Wan, F., Liu, B. and Qian, W. (2023). Inhibition of invasive plant Mikania micrantha rapid growth by host-specific rust (Puccinia spegazzinii). Plant Physiology, 192(2): 1204.

47. Cnubben, N.H.P., Rietjens, I.M.C.M., Wortelboer, H., van Zanden, J. and van Bladeren, P.J. (2001). The interplay of glutathione-related processes in antioxidant defense. Environmental Toxicology. Pharmacology, 2001: 141–152.

48. Patil, J.R., Mhatre, K.J., Yadav, K., Yadav, L.S., Srivastava, S. and Nikalje, G.C. (2024). Flavonoids in plant‑environment interactions and stress responses. Discover Plants, 1:68.

49. Sharma, H.K., Mishra, S. and Kumar, A. (2011). Evaluation of in vitro antioxidant activity of the methanolic extract of the leaves of Mikania micrantha Kunth. Asian Journal of Chemistry. 23(10): 4525–4527.

50. Bera, A., Maiti, S., and Banerjee, N. (2023). A comparative evaluation of antioxidant and antibacterial potential of leaves & flowers of Mikania micrantha Kunth from Paschim Medinipur, West Bengal, India. International Journal of Pharmaceutical Sciences and Research, 14(8): 4003–4008.

51. Zhang, Q., Zhai, J., Shao, L., Lin, W. and Peng, C. (2020). Accumulation of anthocyanins: an adaptation strategy of Mikania micrantha to low temperature in winter. Frontiers in Plant Science. 10: 1796.

52. Clements, D.R. and Kato-Noguchi, H. (2025). Defensive mechanisms of Mikania micrantha likely enhance its invasiveness as one of the World’s Worst Alien Species. Plants, 14: 269.

53. Harahap, N.I., Nainggolan, M. and Harahap, U. (2018). Formulation and evaluation of herbal antibacterial gel containing ethanolic extract of Mikania micrantha Kunth Leaves. Asian Journal Pharmaceutical Clinical Research, 11(3):429.

54. Bora, A.R., Babu, D.S., Kalita, S. and Chetry, S. (2023). Harmful effect of the invasive weed mikania micrantha with special reference to India: A review. Agricultural Reviews, 44(3): 380-384

55. Khan, M.A., El-Kersh, D.M., Islam, M.S., Khan, S.A., Kamli, H., Sarkar, C., Bhuia, M.S., Islam, T., Shill, M.C., Gobe, G.C. and Gürer, E.S. (2023). Mikania micrantha Kunth: An ethnopharmacological treasure trove of therapeutic potential. Chemistry Biodiversity. 20(11): 202300392. 

56. Liu, S.B., Zeng, L., Xu, Q.L., Chen, Y.L., Lou, T., Zhang, S.X. and Tan, J.W. (2022). Polycyclic phenol derivatives from the leaves of Spermacoce latifolia and their antibacterial and α-glucosidase inhibitory activity. Molecules, 27: 3334.

57. Piasecki, B., Biernasiuk, A., Skiba, A., Skalicka-Wo’zniak, K. and Ludwiczuk, A. (2021). Composition, anti-MRSA activity and toxicity of essential oils from Cymbopogon Species. Molecules, 26: 7542.

58. Neog, R. and Kola, N. (2021). In vitro antimicrobial screening of methanolic extract of Mikania micrantha and Drymaria cordata against S. Aureus and its textile application. Materials Today: Proceedings, 42: 916-920.

59. Laurella, L.C., Cerny, N., Bivona, A.E., Alberti, A.S., Giberti, G., Malchiodi, E.L., Martino, V.S., Catalan, C.A., Alonso, M.R., Cazorla, S.I. and Sulsen, V.P. (2017). Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma cruzi and Leishmania sp. PLoS Neglected Tropical Disease, 11: e0005929.

60. Han, J.W., Choi, G.J. and Kim, B.S. (2018). Antimicrobial aromatic polyketides: A review of their antimicrobial properties and potential use in plant disease control. World Journal Microbiology Biotechnology, 34: 163.

61. Yu, H., Le Roux, J.J., Zhao, M. and Li, W. (2023). Mikania sesquiterpene lactones enhance soil bacterial diversity and fungal and bacterial activities. Biology Invasions, 25: 237–250.

62. Yin, L., Liu, B., Wang, H., Zhang, Y., Wang, S., Jiang, F., Ren, Y., Liu, H., Liu, C. and Wan, F. (2020). The rhizosphere microbiome of Mikania micrantha provides insight into adaptation and invasion. Frontier Microbiology, 11: 1462.

63. Kurnia, N.M., Uria, A.R., Kusnadi, Y., Dinawati, L., Zilda, D.S., Hadi, T.A., Setyahadi, S. and Felix, F. (2017). Metagenomic survey of potential symbiotic bacteria and polyketide synthase genes in an Indonesian marine sponge. HAYATI Journal Biosciences, 24: 6-15.

64. Mori, T., Cahn, J.K., Wilson, M.C., Meoded, R.A., Wiebach, V., Martinez, A.F.C., Helfrich, E.J.N., Albersmeier, A., Wibberg, D. and Dätwyler, S. (2018). Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts. Proceeding National Academy Sciences USA, 115: 1718–1723.

65. Jing, C.Y., Fei, P.X., Xin, Z.M., Sheng, D.Q., Ying, D.Y. and Biao, W. (2003). Oviposition repellent of alcohol extracts of 26 non-preferable plant species against citrus leafminer. Journal South China Agric University, 24: 27-29.

66. Zhong, B.Z., Lu, C.J., Wang, D.M., Li, H. and Qin, W. (2012). Effects of methanol extracts of Mikania micrantha on the growth and development of the rhinoceros beetle, Oryctes rhinoceros (Coleoptera: Dynastidae). Acta Entomology Sinica. 55: 1062-1068.

67. Lv, C., Zhong, B., Zhong, G., Weng, Q., Chen, S., Hu, M., Sun, X. and Qin, W. (2012). Four botanical extracts are toxic to the hispine beetle, Brontispa longissima, in laboratory and semi-field trials. Journal Insect Sciences,  12: 58.

68. Den Akker, S.E. (2021). Plant-nematode interactions. Current Opinion Plant Biology, 62: 102035.

69. Dou, X., Zhang, Y., Sun, N., Wu, Y. and Li, L. (2014). The anti-tumor activity of Mikania micrantha aqueous extract in vitro and in vivo. Cytotechnology, 66(1):107-17.

70. Debaprotim, D., Suvakanta, D. and Jashabir. C. (2014). Evaluation of anticancer activity of Mikania micrantha Kunth (asteraceae) against ehrlich ascites carcinoma in Swiss Albino mice. International Journal of Pharmaceutical Research & Allied Sciences, 3(2): 9-18.

71. Lalsangpuii, F., Rokhum, S.L., Nghakliana, F. V. L., Ruatpuia, J., Tochhawng, L., Trivedi, A.K., Lalfakzuala, R. and Siama, Z. (2024). Mikania micrantha silver nanoparticles exhibit anticancer activities against human lung adenocarcinoma via caspase-mediated apoptotic cell death. Artificial Cells, Nanomedicine, and Biotechnology, 52(1):186-200.

72. Bais, H.P., Weir, T.L., Perry, L.G., Gilroy, S. and Vivanco, J.M. (2006). The role of root exudates in rhizosphere interactions with plants and other organisms. Annual Review Plant Biology, 57: 233-266.

73. Bonanomi, G., Sicurezza, M.G., Caporaso, S., Esposito, A. and Mazzoleni, S. (2006). Phytotoxicity dynamics of decaying plant materials. New Phytologist,  169: 571-578.

74. Belz, R.G. (2007). Allelopathy in crop/weed interactions - An update. Pesticde Managament Sciences, 63: 308-326.

75. Ismail, B.S. and Chong, T.V. (2002). Effects of aqueous extracts and decomposition of Mikania micrantha H.B.K. debris on selected agronomic crops. Weed Biology Management, 2: 31-38.

76. Shao, H., Peng, S., Wei, X., Zhang, D. and Zhang, C. (2005). Potential allelochemicals from an invasive weed Mikania micrantha HBK. Journal Chemical Ecology, 31: 1657-1668.

77. Wu, A.P., Huang, Z.Y., Miao, S.L. and Dong, M. (2010). Effects of Mikania micrantha extracts and their exposure time on seed vigour, seed germination and seedling growth of plants. Allelopath Journal,  2: 503-512.

78. Sahid, I. and Yusoff, N. (2014). Allelopathic effects of Chromolaena odorata (L.) King & Robinson and Mikania micrantha H.B.K. on three selected weed species. Australian Journal Crop Sciences, 8: 1024-1028.

79. Jali, P., Samal, I.P., Jena, S. and Mahalik, G. (2021). Morphological and biochemical responses of Macrotyloma uniflorum (Lam.) Verdc. to allelopathic effects of Mikania micrantha Kunth extracts. Heliyon, 7: e07822.

80. Einhellig F.A. (1986). Mechanisms and modes of action of allelochemicals. In: The Science of Allelopathy (ed. by Putnam A.R. and Tang C.S.). John Wiley & Sons, New York. 180- 188.

81. Patterson D.T. (1981). Effects of allelopathic chemicals on growth and physiological responses of soybean (Glycine max). Weed Sciences, 29: 53-59.

82. Leela D. (1995). Allelopathic effects of purple nutsedge (Cyperus rotundus L.) tubers on growth of field crops. Allelopathy Journal, 2: 89-92.

83. Miller H.G., Ikawa M. and Peirce L.C. (1991). Caffeic acid identified as an inhibitory compound in asparagus root filtrate. Hortscience, 26: 1525-1527.

84. Patrick Z.A. (1955). The peach replant problem in Ontario. II. Toxic substance from microbial decomposition products of peach root residues. Canadian Journal Botany, 33: 461-486.

85. Xu, Q., Xie, H., Xiao, H. and Wei, X. (2013). Phenolic constituents from the roots of Mikania micrantha and their allelopathic effects. Journal Agriculture Food Chemistry,  61: 7309-7314.

86. Xu, Q., Xie, H., Xiao, H. and Wei, X. (2013). Two new ent-kaurene diterpene glucosides from the roots of Mikania micrantha. Phytochemistry Letters, 6: 425-428.

87. Ma, H., Chen, Y., Chen, J., Zhang, Y., Zhang, T. and He, H. (2020). Comparison of allelopathic effects of two typical invasive plants: Mikania micrantha and Ipomoea cairica in Hainan Island. Scientific Reports, 10: 11332.

88. Ma, H., Chen, Y., Chen, J., Ji, J. and He, H. (2021). Identification and comparison of allelopathic effects from leaf and flower volatiles of the invasive plants Mikania micrantha. Chemoecology, 31: 355-365.