Malaysian Journal of Analytical Sciences, Vol 28 No 5 (2024): 1210 - 1230
BIOACTIVE PHYTOCHEMICALS AND PHARMACOLOGICAL FACETS OF
Entada SPECIES IN ASIA: A REVIEW
(Kandungan Fitokimia Bioaktif dan
Fakta Farmakologi Spesis Entada di Asia; Satu Ulasan)
Khairil Syazwan Salim1,
Aiza Harun1*, Noorshilawati Abdul Aziz2, Shaari Daud1,
and Siti Zaiton Mat So’ad3
1Faculty of Applied Science,
Universiti Teknologi MARA (UiTM)
Kampus Jengka, 26400 Bandar Tun Abdul Razak Jengka, Pahang, Malaysia
2Faculty of Plantation and Agrotechnology,Universiti Teknologi
MARA (UiTM) Kampus Jengka,
26400 Bandar Tun Abdul Razak Jengka,
Pahang, Malaysia
3Kulliyyah of Pharmacy,International Islamic University
Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia
*Corresponding author: aizaharun@uitm.edu.my
Received:
14 March 2024; Accepted: 2 July 2024; Published: 27 October 2024
Abstract
The genus Entada,
belonging to the family Fabaceae or Leguminosae, is distributed
throughout the tropical and subtropical regions of South America, Australia,
Asia, and Africa. Entada plants exhibit a wide range of pharmacological and
biological properties, and in recent decades, their active metabolites have
garnered significant interest due to their proven beneficial effects in
ethnomedicinal applications and biochemical studies. However, our work only focuses
exclusively on reviewing the Entada species native to and dispersed
throughout the Asian continent. A total of nine species of Entada are
known to be native to Asia. To the best of our knowledge, only three species of
Entada (Entada rheedii, Entada
spiralis, and Entada phaseoloides) have
been studied extensively in Asia. The genus is recognized for its remedial
properties, including anticancer, antibacterial, enzyme inhibitory, antifungal,
antiulcerogenic, antiprotozoal, antioxidant, and antiproliferative activities. This
underscores the relevance of the Entada genus as a rich source of
compounds with significant therapeutic potential.
Keywords: Entada, Entada rheedii, Entada spiralis, Entada
phaseoloides, phytoconstituents
Abstrak
Genus Entada tergolong dalam
keluarga Fabacaea atau Leguminosae, yang tersebar di seluruh
dunia, di kawasan tropika dan sub-tropika di benua Amerika Selatan, Australia,
Asia, dan Afrika. Tumbuhan Entada terdiri daripada pelbagai sifat
farmakologi atau biologi di mana, dalam beberapa dekad kebelakangan ini,
metabolit aktif telah mendapat minat yang ketara disebabkan oleh kesan bermanfaat
yang terbukti dalam penggunaan etnoperubatan dan kajian biokimia. Walau
bagaimanapun, kerja kami hanya menumpukan pada mengkaji genus spesies Entada
yang sedia ada dan tersebar di benua Asia. Sebanyak 9 spesies Entada
diketahui berasal dari benua Asia. Namun, pada pengetahuan kami, hanya 3
spesies Entada (Entada rheedii, Entada spiralis, dan Entada
phaseoloides) yang telah dikaji sehingga kini di Asia. Genus ini diketahui
mempunyai kualiti pemulihan dalam bertindak sebagai antikanser, antibakteria,
perencat enzim, antikulat, antiulserogenik, antiprotozoal, antioksidan, dan
antiproliferatif. Ini menggambarkan bahawa genus Entada adalah relevan
dan mengandungi sumber yang kaya dengan sebatian sifat terapeutik yang tinggi
dan bernilai.
Kata Kunci: Entada, Entada rheedii, Entada
spiralis, Entada phaseoloides, fitokonstituen, aktiviti farmakologi
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