Malaysian Journal of Analytical
Sciences, Vol 28
No 5 (2024): 1087 -
1101
VIRGIN COCONUT OIL-BASED EMULSION AND ITS BENEFITS:
A REVIEW
(Emulsi
Berasaskan Minyak Kelapa Dara dan Kebaikannya: Satu Tinjauan)
Muhammad Afif
Syazani Rozani1, Hairul Amani Abdul Hamid1*, Nursyamsyila
Mat Hadzir1,
Muhammad Alif
Mohammad Latif2, and Ayub Md Som3,4
1School of Chemistry &
Environment, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah
Alam, Selangor, Malaysia
2Department of Chemistry,
Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor,
Malaysia
3School of Chemical Engineering,
College of Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor,
Malaysia
4Industrial Process Reliability
and Sustainability Research Group (INPRES), College of Engineering, Universiti
Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
*Corresponding
author: h.amani@uitm.edu.my
Received: 21 October 2023; Accepted: 14
August 2024; Published: 27 October 2024
Abstract
This review aims to provide a
comprehensive overview of emulsions using virgin coconut oil (VCO) as the
hydrophobic fat component. It focuses on the primary triglycerides in VCO,
which convert into bioactive medium-chain triglycerides (MCTs) with diverse
pharmacological properties. VCO's importance extends to aiding viral and
microbial infections, leveraging its polyphenolic content as a potent
antioxidant, and supporting weight reduction and metabolic improvements
associated with obesity. Derived from Cocos nucifera L., VCO is a
crucial plant-based oil predominantly produced in the Philippines, Malaysia,
and Indonesia; regions where coconuts are in abundance. Despite VCO's extensive
benefits, anti-saturated-fat bias has limited its exposure and acknowledgment
in medical literature. This review addresses this gap, highlighting VCO-based
emulsion applications and advantages for consumers and industries globally. By
examining VCO's properties and its significant contributions to
pharmaceuticals, the study aims to enhance understanding and appreciation of
VCO-based emulsions. The findings underscore the need for broader recognition
of VCO's potential, particularly in combating infections, acting as an
antioxidant, and promoting health benefits linked to weight management and
metabolic health. This review serves as a foundational reference for future
research and development in utilizing VCO within pharmaceutical and
health-related contexts.
Keywords: virgin coconut oil, viral,
antioxidant, polyphenolic, metabolic
Abstrak
Kajian
tinjauan ini berhasrat untuk memberikan gambaran keseluruhan tentang emulsi
yang menggunakan minyak kelapa dara (VCO) bertindak sebagai komponen lemak
hidrofobik. Kajian ini memfokus kepada komponen trigliserida utama dalam VCO
yang ditukar menjadi bioaktif trigliserida rantaian sederhana (MCT) dengan
pelbagai sifat farmakologi. Peripentingnya VCO menjangkaui dalam rawatan
jangkitan virus dan mikrob, dan berpotensi digunakan sebagai enzim antioksidan
kerana kandungan polifenolnya. Ia juga membantu dalam pengurangan berat badan
dan penambahbaikan penunjuk metabolik yang berkaitan dengan obesiti. VCO ialah
minyak yang dihasilkan daripada tumbuhan Cocos nucifera L., yang
merupakan salah satu tumbuhan terpenting di dunia yang boleh didapati di
Filipina, Malaysia, dan Indonesia, iaitu negara-negara yang kaya dengan kelapa.
Walaupun banyak kelebihan VCO dilaporkan secara meluas, namun prasangka
anti-lemak-tepu semasa telah membataskan penularan dan penerimaannya dalam
bidang perubatan. Kajian ini bertujuan untuk merapatkan jurang tersebut dengan
memberi pencerahan mengenai aplikasi emulsi berasaskan VCO, faedahnya kepada
pengguna serta industri di seluruh dunia. Dengan menjalankan penyelidikan
mengenai sifat-sifat semulajadi VCO dan sumbangan pentingnya kepada industri
farmaseutikal, kajian ini dapat merangsang kefahaman dan penghargaan yang lebih
baik tentang emulsi berasaskan VCO. Penemuan dalam kajian ini diharapkan dapat
memberi pengiktirafan meluas mengenai potensi VCO terutamanya berperanan
sebagai antioksidan dalam mencegah jangkitan penyakit, dan mempromosi pelbagai
khasiat yang merujuk kepada pengurusan berat badan serta kesihatan metabolik.
Ia juga boleh menjadi satu rujukan asas untuk penyelidikan serta pembangunan
dalam penggunaan VCO pada masa hadapan bagi sektor industri farmaseutikal dan
kesihatan.
Kata kunci: minyak
kelapa dara, virus, antioksidan, polifenolik, metabolik
References
1. Lukić, I., Kesic, Z., Zdujić, M., and Skala, D. (2016). Vegetable oil as a
feedstock for biodiesel synthesis. Nova Science Publisher: pp. 83-127
2. Srivastava, Y., Semwal, A. D., and Sharma, G. K.
(2018). Virgin coconut oil as functional oil. In Therapeutic, Probiotic, and
Unconventional Foods (pp. 291–301). Elsevier.
3. Lima, E. B. C., Sousa, C. N. S., Meneses, L. N.,
Ximenes, N. C., Santos Júnior, M. A., Vasconcelos, G. S., Lima, N. B. C., Patrocínio, M. C. A., Macedo, D., and Vasconcelos, S. M. M.
(2015). Cocos nucifera (L.) (Aceraceae): A phytochemical and
pharmacological review. Brazilian Journal of Medical and Biological
Research, 48(11): 953-964.
4. Mathew, M. T., Baby, P. O., Sukumaran, P. A., and Menachery, P. A. (2011). Global Coconut Scenario &
WTO Global Competitiveness of Indian Coconut oil-an Outlook.
5. Agarwal, R. K. (2017). Extraction processes of virgin
coconut oil. MOJ Food Processing & Technology, 4(2): 00087.
6. Onsaard, E., Vittayanont, M., Srigam, S., and McClements, D. J. (2005). Properties and
stability of oil-in-water emulsions stabilized by coconut skim milk proteins. Journal
of Agricultural and Food Chemistry, 53(14): 5747-5753.
7. Raghavendra, S. N., and Raghavarao,
K. S. M. S. (2010). Effect of different treatments for the destabilization of
coconut milk emulsion. Journal of Food Engineering, 97(3): 341-347.
8. Rosenthal, A., Pyle, D. L., and Niranjan, K. (1996).
Aqueous and enzymatic processes for edible oil extraction. Enzyme and
Microbial Technology, 19(6): 402-420.
9. Boateng, L., Ansong, R., Owusu, W. B., and
Steiner-Asiedu, M. (2016). Coconut oil and palm oil’s role in nutrition, health
and national development: A review. Ghana Medical Journal, 50(3):
189-196.
10. DebMandal, M., and Mandal, S. (2011). Coconut (Cocos
nucifera L.: Aceraceae): In health promotion and disease prevention.
Asian Pacific Journal of Tropical Medicine, 4(3): 241-247.
11. Marina, A. M., Che Man, Y. B., Nazimah, S. A. H., and
Amin, I. (2009). Antioxidant capacity and phenolic acids of virgin coconut oil.
International Journal of Food Sciences and Nutrition, 60: 114-123.
12. Obidoa, O., Joshua, P. E., and Eze, N. J. (2010).
Phytochemical analysis of Cocos nucifera L. Journal of Pharmacy
Research, 3(2): 280-286.
13. Hewlings, S. (2020). Coconuts and health: Different chain
lengths of saturated fats require different consideration. Journal of
Cardiovascular Development and Disease, 7(4): 1-15.
14. Ghosh, P. K., Bhattacharjee, P., Mitra, S., and
Poddar-Sarkar, M. (2014). Physicochemical and phytochemical analyses of copra
and oil of Cocos nucifera L. (West coast tall variety). International
Journal of Food Science, 2014(1): 310852.
15. Nyayiru Kannaian, U. P., Edwin, J.
B., Rajagopal, V., Nannu Shankar, S., and Srinivasan,
B. (2020). Phytochemical composition and antioxidant activity of coconut
cotyledon. Heliyon, 6(2): 03411.
16. Kaur, R. A. J. B. I. R., and Arora, S. A. R. O. J.
(2015). Alkaloids-important therapeutic secondary metabolites of plant origin. Journal
Critical Reviews, 2(3): 1-8.
17. Heinrich, M., Mah, J., and Amirkia,
V. (2021). Alkaloids used as medicines: Structural phytochemistry meets
biodiversity—An update and forward look. Molecules, 26(7): 1836.
18. Kurek, J. (2019). Introductory chapter: Alkaloids -
their importance in nature and for human life. In Alkaloids - Their
Importance in Nature and Human Life. IntechOpen.
19. Tong, Z., He, W., Fan, X., and Guo, A. (2022).
Biological function of plant tannin and its application in animal health. Frontiers
in Veterinary Science, 8: 803657.
20. Tamura, Y., Miyakoshi, M., and Yamamoto, M. (2012).
Application of Saponin-Containing Plants in Foods and Cosmetics. Alternative
Medicine. InTech: pp. 85-101.
21. Kregiel, D., Berlowska, J., Witonska, I., Antolak, H., Proestos,
C., Babic, M., ... and Zhang, B. (2017). Saponin-based, biological-active
surfactants from plants. Application and characterization of
Surfactants, 6(1): 184-205.
22. Evans, W. C. (2009). Trease and Evans'
pharmacognosy. Elsevier Health Sciences.
23. Kardinasari, E., and Devriany, A. (2020). Phytochemical identification of Bangka
origin virgin green coconut oil: Anti-inflammatory and anti-bacterial
potential. Enfermeria Clinica,
30: 171-174.
24. Jadhav, H. B., and Annapure,
U. S. (2023). Triglycerides of medium-chain fatty acids: a concise review. In Journal
of Food Science and Technology, 60(8): 2143-2152.
25. Jack, K. S., Asaruddin, M.
R. Bin, and Bhawani, S. A. (2022). Pharmacophore study, molecular docking and
molecular dynamic simulation of virgin coconut oil derivatives as
anti-inflammatory agent against COX-2. Chemical and Biological Technologies
in Agriculture, 9(1): 73.
26. Gondokesumo, M. E., Sapei, L., Wahjudi, M., Suseno,
N., and Adiarto, T. (2022). Molecular mechanism of
virgin coconut oil as a Nsp-3 inhibitor of SARS-CoV-2. Asia Pacific Journal
Molecular Biology Biotechnology, 30(4): 9-19.
27. Shah, N. D., and Limketkai,
B. N. (2017). The use of medium-chain triglycerides in gastrointestinal
disorders. Practical Gastroenterology, 160: 20-25.
28. Joshi, S., Kaushik, V., Gode, V., and Mhaskar, S.
(2020). Coconut oil and immunity: what do we really know about it so far. Journal
of Association Physicians India, 68(7): 67-72.
29. Subroto, E., and Indiarto,
R. (2020). Bioactive monolaurin as an antimicrobial and its potential to
improve the immune system and against covid-19: A review. Food Research,
4(6): 2355-2365.
30. Hee, Y. Y., Tan, C. P., Rahman, R. A., Noranizan, M., Smith, R. L., and Chong, G. H. (2017).
Production of virgin coconut oil microcapsules from oil-in-water emulsion with
supercritical carbon dioxide spray drying. Journal of Supercritical Fluids,
130(7): 118-124.
31. Suryani, S., Sariani, S., Earnestly, F., Marganof, M., Rahmawati, R., Sevindrajuta,
S., Indra Mahlia, T. M., and Fudholi, A. (2020). A
comparative study of virgin coconut oil, coconut oil and palm oil in terms of
their active ingredients. Processes, 8(4): 402.
32. Roopashree, P. G., Shetty, S. S., & Kumari, N. S.
(2021). Effect of medium chain fatty acid in human health and disease. Journal
of Functional Foods, 87: 104724.
33. Abujazia, M. A., Muhammad, N., Shuid,
A. N., and Soelaiman, I. N. (2012). The effects of
virgin coconut oil on bone oxidative status in ovariectomised rat. Evidence-Based
Complementary and Alternative Medicine, 2012(1): 525079.
34. Mozaffarian, D.,
Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S.
R., Ferranti, S. De, Després, J. P., Fullerton, H. J., Howard, V. J., Huffman,
M. D., Isasi, C. R., Jiménez, M. C., Judd, S. E., Kissela,
B. M., Lichtman, J. H., Lisabeth, L. D., Liu, S., … Turner, M. B. (2016). Heart
disease and stroke statistics-2016 update a report from the American Heart
Association. Circulation, 133(4): e38-e48.
35. Nurul-Iman, B. S., Kamisah, Y., Jaarin,
K., and Qodriyah, H. M. S. (2013). Virgin coconut oil
prevents blood pressure elevation and improves endothelial functions in rats
fed with repeatedly heated palm oil. Evidence-Based Complementary and
Alternative Medicine, 2012(1): 525079.
36. Dumancas, G., Kasi, Viswanath LC, and de Leon AR (2016).
Health benefits of virgin coconut oil (Brittany Holt, Ed.). Nova Science
Publishers, Inc.
37. Mohammed, N. K., Samir, Z. T., Jassim, M. A., and
Saeed, S. K. (2021). Effect of different extraction methods on physicochemical
properties, antioxidant activity, of virgin coconut oil. Materials Today:
Proceedings, 42: 2000-2005.
38. Wiyani, L., Aladin, A., Mustafiah,
Abriana, A., and Rahmawati. (2020). Characteristics of Virgin Coconut Oil
Emulsion with Honey and Citric Acid. 194(FANRes
2019): pp. 246-250.
39. Varma, S. R., Sivaprakasam, T. O., Arumugam, I.,
Dilip, N., Raghuraman, M., Pavan, K. B., Rafiq, M., and Paramesh, R. (2019). In
vitro anti-inflammatory and skin protective properties of Virgin coconut oil. Journal
of Traditional and Complementary Medicine, 9(1): 5-14.
40. Varma, S. R., Sivaprakasam, T. O., Arumugam, I.,
Dilip, N., Raghuraman, M., Pavan, K. B., Rafiq, M., and Paramesh, R. (2019). In
vitro anti-inflammatory and skin protective properties of Virgin coconut oil. Journal
of Traditional and Complementary Medicine, 9(1): 5-14.
41. Dayrit, F. M. (2015). The properties of lauric acid
and their significance in coconut oil. Journal of the American Oil Chemists’
Society, 92(1): 1-15.
42. Nitbani, F. O., Tjitda, P. J. P.,
Nitti, F., Jumina, J., and Detha,
A. I. R. (2022). Antimicrobial properties of lauric acid and monolaurin in
virgin coconut oil: A review. Chemical Biology Engineering Reviews,
9(5): 442-461.
43. Projan, S. J., Brown-Skrobot, S., Schlievert, P. M., Vandenesch, F., & Novick, R. P. (1994). Glycerol
monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and
other staphylococcal exoproteins by interfering with signal transduction. Journal
of Bacteriology, 176(14): 4204-4209.
44. Beceiro, A., Tomás, M., and Bou, G. (2013). Antimicrobial
resistance and virulence: A successful or deleterious association in the
bacterial world? Clinical Microbiology Reviews, 26(2): 185-230.
45. Bhatt, K. (2021). Antioxidant, antibacterial,
antiviral and antifungal properties of virgin coconut oil (VCO). Journal of
Nutritional Biology, 7(1): 1-10.
46. Tangwatcharin, P., and Khopaibool, P. (2012). Activity of virgin coconut oil,
lauric acid or monolaurin in combination with lactic acid against
Staphylococcus aureus. Southeast Asian Journal of Tropical Medicine
& Public Health, 43(4): 969-985.
47. Sihombing, N. T., Silalahi, J., and Suryanto, D. (2014). Antibacterial activity of aqueous
garlic (Allium sativum) extracts and virgin coconut oil and their combination
against Bacillus cereus ATCC 14579 and Escherichia coli ATCC
8939. International Journal of ChemTech Research,
6(5): 2774-2782.
48. Hess, D. J., Henry-Stanley, M. J., and Wells, C. L.
(2015). The natural surfactant glycerol monolaurate significantly reduces
development of Staphylococcus aureus and Enterococcus faecalis biofilms.
Surgical Infections, 16(5): 538-542.
49. Shilling, M., Matt, L., Rubin, E., Visitacion, M. P.,
Haller, N. A., Grey, S. F., and Woolverton, C. J. (2013). Antimicrobial effects
of virgin coconut oil and its medium-chain fatty acids on clostridium
difficile. Journal of Medicinal Food, 16(12): 1079-1085.
50. Skřivanová, E., Marounek, M., Dlouhá, G., and Kaňka,
J. (2005). Susceptibility of Clostridium perfringens to C2-C18 fatty
acids. Letters in Applied Microbiology, 41(1): 77-81.
51. Anzaku, A. A., Akyala, J. I.,
Juliet, A., and Obianuju, E. C. (2017). Antibacterial activity of lauric acid
on some selected clinical isolates. Annals of Clinical and Laboratory
Research, 5(2): 1-5.
52. Ströher, D. J., De Oliveira, M. F., Martinez-Oliveira, P.,
Pilar, B. C., Cattelan, M. D. P., Rodrigues, E., Bertolin,
K., Gonçalves, P. B. D., Piccoli, J. D. C. E., and Manfredini, V. (2020).
Virgin coconut oil associated with high-fat diet induces metabolic
dysfunctions, adipose inflammation, and hepatic lipid accumulation. Journal
of Medicinal Food, 23(7): 689-698.
53. Deol, P., Evans, J. R., Dhahbi,
J., Chellappa, K., Han, D. S., Spindler, S., & Sladek, F. M. (2015).
Soybean oil is more obesogenic and diabetogenic than coconut oil and fructose
in mouse: potential role for the liver. PloS
one, 10(7): e0132672.
54. Makris, A., and Foster, G. D. (2011). Dietary
approaches to the treatment of obesity. Psychiatric Clinics of North
America, 34(4): 813-827.
55. Kang, J. G., and Park, C. Y. (2012). Anti-obesity
drugs: A review about their effects and safety. Diabetes and Metabolism
Journal, 36(1): 13-25.
56. Vogel, C. É., Crovesy, L.,
Rosado, E. L., and Soares-Mota, M. (2020). Effect of coconut oil on weight loss
and metabolic parameters in men with obesity: A randomized controlled clinical
trial. Food and Function, 11(7): 6588-6594.
57. Babu, A. S., Veluswamy, S.
K., Arena, R., Guazzi, M., and Lavie, C. J. (2014).
Virgin coconut oil and its potential cardioprotective effects. Postgraduate
Medicine, 126(7): 76-83.
58. Papamandjaris, A. A., Macdougall, D. E., and Jones, P. J. H. (1998). Minireview
medium chain fatty acid metabolism and energy expenditure: Obesity treatment
implications. Life Scieacea, 62(14): 1203-1215.
59. Ikeda, Y., Okamura-Ikeda, K., and Tanaka, K. (1985).
Purification and characterization of short-chain, medium-chain, and long-chain
acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and
apoenzymes and conversion of the apoenzyme to the holoenzyme. Journal of
Biological Chemistry, 260(2): 1311-1325.
60. Zeb, A. (2020). Concept, mechanism, and applications
of phenolic antioxidants in foods. Journal of Food Biochemistry, 44(9):
e13394.
61. Seneviratne, K. N., HapuarachchI,
C. D., and Ekanayake, S. (2009). Comparison of the phenolic-dependent
antioxidant properties of coconut oil extracted under cold and hot conditions. Food
Chemistry, 114(4): 1444–1449.
62. Sundrasegaran, S., and
Mah, S. H. (2020). Extraction methods of virgin coconut oil and
palm‐pressed mesocarp oil and their phytonutrients. eFood,
1(6): 381-391.
63. Seneviratne, K. N., and Sudarshana Dissanayake, D. M.
(2008). Variation of phenolic content in coconut oil extracted by two
conventional methods. International Journal of Food Science and Technology,
43(4): 597-602.
64. Shahidi, F., and Zhong, Y. (2015). Measurement of
antioxidant activity. Journal of Functional Foods, 18: 757-781.
65. Som, A. M., Ahmat, N., Abdul Hamid, H. A., and Azizuddin, N. (2019). A comparative study on foliage and
peels of Hylocereus undatus (white dragon
fruit) regarding their antioxidant activity and phenolic content. Heliyon, 5(2): e01244.
66. Wiyani, L., and Aladin, A. (2020). Antioxidant activity of
virgin coconut oil and virgin coconut oil emulsion.
67. Abd Rashid, S. N. A., Misson, M., Yaakob, H., Latiff,
N. A., & Sarmidi, M. R. (2017). Addition of
virgin coconut oil: Influence on the nutritional value and consumer acceptance
of dark chocolate. Transaction Science Technology, 4(3-3):
426-431.
68. Jayathilaka, N., and Seneviratne, K. N. (2022).
Phenolic antioxidants in coconut oil: Factors affecting the quantity and
quality. A review. Grasas y Aceites, 73(3):
e466-e466.
69. Angeles-Agdeppa, I., Nacis,
J. S., Capanzana, M. V., Dayrit, F. M., and Tanda, K.
V. (2021). Virgin coconut oil is effective in lowering C-reactive protein
levels among suspect and probable cases of COVID-19. Journal of Functional
Foods, 83: 104557.
70. Dacasin, A. B., Diagono, D.
M. B., So, P. K. N., Bautista, V. R. L., Bucu, M. L.
B., Grano, R. V. R. De, Yu, G. F. B., and Bueno, P. R. P. (2021). The potential
use of virgin coconut oil as an adjunctive treatment for COVID-19: A review. Journal
of Pharmacognosy and Phytochemistry, 10(6): 37-49.