Malaysian Journal of Analytical Sciences Vol 21 No 5 (2017): 1162 - 1167

DOI: https://doi.org/10.17576/mjas-2017-2105-20

 

 

 

IRON(II) COMPLEX OF ANTHRAQUINONE: SYNTHESIS, STRUCTURAL ELUCIDATION AND ANTIMICROBIAL ACTIVITY

 

(Komplek Ferum(II) Antrakuinon: Sintesis, Penentuan Struktur Organik dan Aktiviti Antimikrob)

 

Nur Dzaina Zaidel, Vivien Jong Yi Mian*, Mohammad Isa Mohamadin

 

Faculty of Applied Sciences

Universiti Teknologi MARA, 94300 Kota Samarahan, Sarawak, Malaysia

 

*Corresponding author:  vivien@sarawak.uitm.edu.my

 

 

Received: 21 August 2016; Accepted: 27 July 2017

 

 

Abstract

Our continuing interest in anthraquinone had led the researchers to look at the synthesis of metal complex by reacting our major compound, nordamnacanthal with transition metal, Fe(II). Fe(II)-nordamnacanthal complex had been synthesized successfully via telescoping synthesis/ one-pot reaction. The ligand and its metal complex were established by 1D and 2D nuclear magnetic resonance spectroscopy, UV-Visible, CHNS analyzer, gas chromatography mass spectrometry and infrared analysis. They were evaluated for their antimicrobial activity using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Fe(II)-nordamnacanthal complex showed stronger inhibition against Pseudomonas aeruginosa at the concentration of 450 µg/mL while Proteus vulgaris, Klebsiella pneumoniae and Salmonella pneumoniae at the concentration of 225 µg/mL compare to nordamnacanthal. In this work, the synthesized compound, Fe(II)-nordamnacanthal showed better antimicrobial activity compared to the ligand itself.

 

Keywords:  nordamnacanthal, transition metal Fe(II), Fe(II)-nordamnacanthal complex, antimicrobial activity

 

Abstrak

Kesinambungan perhatian kami terhadap antrakuinon telah membawa kami untuk melihat kepada sintesis kompleks logam dengan menghasilkan tindak balas sebatian utama kami, nordamnacanthal dengan logam peralihan, Fe(II). Kompleks Fe(II)-nordamnacanthal telah berjaya disintesiskan melalui teleskop sintesis/tindak balas satu-periuk. Sebatian dan kompleks logam dikenalpasti melalui 1D dan 2D spektroskopi resonan magnetik nukleus, UV-Vis, CHNS, kromatografi gas spektometri jisim dan analisis inframerah. Sebatian dan kompleks logam tersebut telah dinilai untuk aktiviti antimikrob dengan menggunakan kepekatan perencatan minimum (MIC) dan minimum kepekatan bakteria (MBC). Kompleks Fe(II)-nordamnacanthal menunjukkan perencatan yang kuat terhadap Pseudomonas aeruginosa pada kepekatan 450 µg/mL manakala Proteus vulgaris, Klebsiella pneumoniae dan Salmonella pneumoniae pada kepekatan 225 µg/mL berbanding dengan nordamnacanthal. Dalam kajian ini, sebatian yang disintesis, kompleks Fe(II)-nordamnacanthal menunjukkan aktiviti antimikrob lebih baik berbanding dengan sebatian itu sendiri.

 

Kata kunci:  nordamnacanthal, logam peralihan Fe(II), kompleks Fe(II)-nordamnacanthal, aktiviti antimikrob

 

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