Malaysian Journal of Analytical Sciences Vol 20 No 4 (2016): 870 - 876

DOI: http://dx.doi.org/10.17576/mjas-2016-2004-22

 

 

 

SYNTHESIS AND CHARACTERIZATION OF BISCOUMARIN AND BENZOPYRANO DICOUMARIN DERIVATIVES

 

(Sintesis dan Pencirian Terbitan Biskumarin dan Benzopirano Dikumarin)

 

Nik Khairunissa’ Nik Abdullah Zawawi1,2, Muhammad Taha1,2, Norizan Ahmat1,2*, Nor Hadiani Ismail1,2

 

1Faculty of Applied Sciences,

Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

2Atta-ur-Rahman Institute for Natural Product Discovery,

Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia

 

*Corresponding author: noriz118@salam.uitm.edu.my

 

 

Received: 24 February 2015; Accepted: 27 October 2015

 

 

Abstract

The wide-ranging biological activities of 4-hydroxycoumarin have stimulated considerable interest in this class of compounds, and various biscoumarin derivatives have been synthesized. Recently, a number of methods have been reported for the synthesis of biscoumarin by the reaction of 4-hydroxycoumarin and various aldehydes in the presence of catalysts. In the present study, a new series of biscoumarin and benzopyrano dicoumarin were synthesized and physically characterized by nuclear magnetic resonane (1H and 13C NMR), fourier transform infrared spectroscopy (FTIR), mass spectrometry (MS) and melting point.

 

Keywords:  synthesis, 4-hydroxycoumarin, biscoumarin, benzopyrano, nuclear magnetic resonane

 

Abstrak

Aktiviti biologi yang meluas daripada 4-hydroksikumarin telah merangsang minat yang besar di dalam kelas sebatian ini dan pelbagai terbitan biskumarin telah disintesis. Baru-baru ini, beberapa kaedah telah dilaporkan bagi sintesis biskumarin melalui tindak balas 4-hidroksikumarin dan pelbagai aldehid dengan kehadiran pemangkin. Dalam kajian ini, satu siri baru biskumarin dan benzopyrano dikumarin telah disintesis dan telah dicirikan secara fizikal oleh resonans magnet nukleus (1H dan 13C NMR), spektroskopi infra merah transformasi Fourier (FTIR), spektrometri jisim (MS) dan pengukuran takat lebur .

 

Kata kunci:  sintesis, 4-hidroksikumarin, biskumarin, benzopirano, resonans magnet nukleus

 

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