The Malaysian Journal of Analytical Sciences Vol 17 No 2 (2013): 281 – 285

 

 

 

STEROIDAL COMPOUNDS FROM THE ROOTS OF

HOLARRHENA CURTISII

 

(Sebatian Steroid daripada Akar Holarrhena curtisii)

 

Noor Fazila Zahari*, Ikram M. Said

 

School of Chemical Science and Food Technology, Faculty of Science and Technology

Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor D.E.

 

*Corresponding author: fazilazahari@yahoo.com

 

 

Abstract

Two known steroidal compounds namely pregnenolone (1), an androstane steroid [3-hydroxypreg-5-en-20-one] and stigmasterol (2) [stigmasta-5,22-dien-3β-ol] have been isolated from methanol extract of the  roots of Holarrhena curtisii by using several chromatographic means. Their structures were elucidated through a combination of NMR, IR and GC-MS techniques by comparison with the data obtained from the literature. Separation of pregnenolone and stigmasterol from the Holarrhena curtisii has never been reported.

 

Keyword: Apocynaceae, Holarrhena curtisii, roots, steroids, pregnenolone, stigmasterol

 

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