The Malaysian Journal of Analytical Sciences Vol 16 No 1 (2012): 56 – 61

 

 

 

SYNTHESIS, CHARACTERISATION AND ANTIBACTERIAL STUDIES OF Cu(II) COMPLEXES THIOUREA

 

(Sintesis, Pencirian dan Kajian Aktiviti Antibakteria Kompleks Cu(II) Tiourea)

 

Nur Illane Mohamad Halim^1*, Karimah Kassim¹, Adibatul Husna Fadzil¹, Bohari M. Yamin²

 

¹Faculty of Applied Sciences,

Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

²School of Chemical Sciences and Food Technology, Faculty of Science and Technology,

Universiti Kebangsaan Malaysia, 43650 UKM Bangi, Selangor, Malaysia

 

*Corresponding author: m.hnurillane@yahoo.com

 

 

Abstract

A series of bisthiourea ligands, 1,2-bis(N’-2-methoxybenzoylthioureido)-4-chlorobenzene (TI), 1,2-bis(N’-3-methoxy benzoylthioureido)-4-chlorobenzene (TII)  and 1,2-bis(N’-4-methoxybenzoylthioureido)-4-chlorobenzene (TIII) and their Cu(II) complexes have been successfully synthesised. The products have been characterised by elemental analysis (CHNS), IR spectroscopy, ¹H and ¹³C Nuclear Magnetic Resonance (NMR), melting point and magnetic susceptibility determination method. The values of μ_eff (B.M) for Cu(II) complexes in the range of 1.23-2.21 B.M reveal that the complexes are square planar geometry. The thiourea ligands along with their respective Cu(II) complexes were screened for their antibacterial activity using disc diffusion method against four strains of bacteria (Bacillus subtillis, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus). Interestingly, compound TIII, Cu(TII) and Cu(TIII) showed the activity against Staphylococcus aureus. The antibacterial activity of their metal complexes is higher than the ligands.

 

Keywords: Bisthiourea, spectroscopy, antibacterial activity

 

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