The Malaysian Journal of Analytical Sciences Vol 16 No 1 (2012): 88 – 93

 

 

 

FLUORINE-18: CURRENT APPROACH IN RADIOLABELLING AND RADIATION SAFETY ASPECTS

 

(Fluorin-18: Pendekatan Semasa dalam Pengradiopenglabelan dan Aspek Keselamatan Sinaran)

 

Suzilawati Muhd Sarowi¹*, Noriah Ali¹ and Noratikah Mat Ail²

 

¹Radiation Safety Division,

Malaysian Nuclear Agency, 43000 Kajang, Selangor, Malaysia.

²Nuclear Medicine Department,

Ground Floor, Putrajaya Hospital,Precinct 7, 62250 Putrajaya, Malaysia.

 

*Corresponding author: suzie@nuclearmalaysia.gov.my

 

 

Abstract

Positron Emission Tomography (PET) imaging has currently become an important technique to study physiological, biochemical and pharmacological functions in humans. The radiopharmaceuticals or tracers for the PET scan incorporating the positron emitting radioisotopes such as Fluorine-18, Carbon-11, Nitrogen-13 and Oxygen-15. A Fluorine -18 (¹⁸F) is oftenly used in development of radiopharmaceuticals due to its favourable physical and nuclear characteristics. By far, the most common radiopharmaceutical used in PET imaging is 2-[¹⁸F]-fluoro-2-deoxy-D-glucose, or [¹⁸F]FDG. There are several approaches in radiolabelling using ¹⁸F and the disadvantage is the time consuming multi-step reactions. Therefore, there is a need to make the radiolabelling prosess more speedy. Once working with radionuclide, the radiation safety is concerned and must be addressed. This paper will discuss on the current approach in the ¹⁸F radiolabelling using  “click reaction” based on paper review and a practical aspects of radiation safety. The advantages of this system are cheap, does not require an inert atmosphere, can be perfomed in the presence of water and eliminates the need for a base. As a result, the radiolabelling prosess can be performed in shorter time and a good yield.

 

Keywords:  Fluorine-18, click reaction and radiation safety

 

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