The Malaysian Journal of Analytical Sciences Vol 15 No 1 (2011): 93 – 100

 

 

 

SYNTHESIS, CHARACTERIZATION AND NEUROTOXIC EFFECT OF SCHIFF BASE LIGANDS AND THEIR COMPLEXES

 

Ahmad Fauzi Abu Bakar1*, Hadariah Bahron1, Karimah Kassim1, Mazatulikhma Mat Zain2

 

1Department of Chemistry, Faculty of Applied Sciences,

2Institute of Science (IOS),

Universiti Teknologi MARA

40450 Shah Alam, Selangor, Malaysia

 

*Corresponding author: fauzi_charming@yahoo.com

 

 

Abstract

Two ligands and eight complexes are successfully synthesized by reacting 1,8-diaminonapthelene with aldehyde/ketone derivatives in 1:2 ratio for ligand formation and 1:1 ratio for complex formations. The compounds are characterized through CHN elemental anaysis, IR spectroscopy, 1H NMR spectroscopy, melting point and magnetic susceptibility determination. The neurotoxicity of compounds is evaluated using neuroblastoma SH-SY5Y cell lines and it was indicate the cells were non-toxic either for ligands and complexes after 24 hours exposure.

 

Keywords: Schiff base, 1,8-diaminonaphthalene, neurotoxicity, SH-SY5Y cell lines

 

References

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